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MeSH Review

Muscle Fatigue

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Disease relevance of Muscle Fatigue


Psychiatry related information on Muscle Fatigue


High impact information on Muscle Fatigue

  • N-acetylcysteine inhibits muscle fatigue in humans [7].
  • The highly significant linear relationship between increases of H+ and H2PO4- and the decline of MVC strongly suggests that both H+ and H2PO4- are important determinants of human muscle fatigue [8].
  • The goal of these experiments was to investigate the relationship of ATP, phosphocreatine (PCr), inorganic phosphate (Pi), monobasic phosphate (H2PO4-), and pH to human muscle fatigue [8].
  • We have identified a 38-year-old man who has a lifelong condition of fishlike body odor and chronic muscle fatigue, accompanied by elevated levels of the muscle form of creatine kinase in serum [9].
  • We conducted a prospective trial to evaluate a global muscle fatigue parameter--the blood lactate level achieved at maximal exercise--as a method of distinguishing between diseased and nondiseased coronary status [10].

Chemical compound and disease context of Muscle Fatigue


Biological context of Muscle Fatigue


Anatomical context of Muscle Fatigue


Associations of Muscle Fatigue with chemical compounds


Gene context of Muscle Fatigue

  • CONCLUSION: The results of this study suggest that COX-2-selective inhibition has a beneficial effect on muscle fatigue resistance in hospitalized elderly patients with acute inflammation of infectious origin [31].
  • Our data suggest that systemic ablation of sarcalumenin caused enhanced resistance to muscle fatigue by compensatory changes in Ca2+ regulatory proteins that effect SOCE [32].
  • Thus, muscle-derived NT-4 is required for maintenance of postsynaptic AChR regions, normal muscular electrophysiological responses, and resistance to muscle fatigue [21].
  • It is proposed that MCT1 expression may be important for blood lactate removal after supramaximal exercise based on the existence of lactate shuttles and, in turn, in favor of a better tolerance to muscle fatigue [33].
  • Thus, we conclude that the PD may be a good index of the overload of the respiratory movement and available to predict muscle fatigue in COPD patients [34].

Analytical, diagnostic and therapeutic context of Muscle Fatigue


  1. Hyperoxia and moderate hypoxia fail to affect inspiratory muscle fatigue in humans. Ameredes, B.T., Clanton, T.L. J. Appl. Physiol. (1989) [Pubmed]
  2. Biochemistry of exercise-induced metabolic acidosis. Robergs, R.A., Ghiasvand, F., Parker, D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  3. Pregnancy with cytochrome oxidase-deficient mitochondrial myopathy. Soccio, P.S., Phillips, W.P., Bonisteel, P., Bennett, K.A. Obstetrics and gynecology. (2001) [Pubmed]
  4. Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. Greenhaff, P.L., Campbell-O'Sullivan, S.P., Constantin-Teodosiu, D., Poucher, S.M., Roberts, P.A., Timmons, J.A. British journal of clinical pharmacology. (2004) [Pubmed]
  5. Muscle force, perceived effort, and voluntary activation of the elbow flexors assessed with sensitive twitch interpolation in fibromyalgia. Miller, T.A., Allen, G.M., Gandevia, S.C. J. Rheumatol. (1996) [Pubmed]
  6. Habitual level of physical activity and muscle fatigue of the elbow flexor muscles in older men. Seghers, J., Spaepen, A., Delecluse, C., Colman, V. European journal of applied physiology. (2003) [Pubmed]
  7. N-acetylcysteine inhibits muscle fatigue in humans. Reid, M.B., Stokić, D.S., Koch, S.M., Khawli, F.A., Leis, A.A. J. Clin. Invest. (1994) [Pubmed]
  8. 31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. Comparison of aerobic and anaerobic exercise. Miller, R.G., Boska, M.D., Moussavi, R.S., Carson, P.J., Weiner, M.W. J. Clin. Invest. (1988) [Pubmed]
  9. Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency. Binzak, B.A., Wevers, R.A., Moolenaar, S.H., Lee, Y.M., Hwu, W.L., Poggi-Bach, J., Engelke, U.F., Hoard, H.M., Vockley, J.G., Vockley, J. Am. J. Hum. Genet. (2001) [Pubmed]
  10. Maximal blood lactate level acts as a major discriminant variable in exercise testing for coronary artery disease detection in men. Barthélémy, J.C., Roche, F., Gaspoz, J.M., Geyssant, A., Minini, P., Antoniadis, A., Page, E., Wolf, J.E., Wilner, C., Isaaz, K., Cavallaro, C., Lacour, J.R. Circulation (1996) [Pubmed]
  11. Treatment of myasthenia gravis with mycophenolate mofetil: a case report. Meriggioli, M.N., Rowin, J. Muscle Nerve (2000) [Pubmed]
  12. An animal model of mitochondrial myopathy: a biochemical and physiological investigation of rats treated in vivo with the NADH-CoQ reductase inhibitor, diphenyleneiodonium. Cooper, J.M., Petty, R.K., Hayes, D.J., Challiss, R.A., Brosnan, M.J., Shoubridge, E.A., Radda, G.K., Morgan-Hughes, J.A., Clark, J.B. J. Neurol. Sci. (1988) [Pubmed]
  13. Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Jones, M.G., Goodwin, C.S., Amjad, S., Chalmers, R.A. Clin. Chim. Acta (2005) [Pubmed]
  14. Hyperinsulinaemia in ischaemic heart disease: the importance of myocardial infarction and left ventricular function. Wright, R.A., Flapan, A.D., Stenhouse, F., Simpson, C., Flint, L., Boon, N.A., Alberti, K.G., Reimersma, R.A., Fox, K.A. Q. J. Med. (1994) [Pubmed]
  15. Effect of oral L-carnitine on serum myoglobin in hemodialysis patients. Feinfeld, D.A., Kurian, P., Cheng, J.T., Dilimetin, G., Arriola, M.R., Ward, L., Manis, T., Carvounis, C.P. Renal failure. (1996) [Pubmed]
  16. Effects of N-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Matuszczak, Y., Farid, M., Jones, J., Lansdowne, S., Smith, M.A., Taylor, A.A., Reid, M.B. Muscle Nerve (2005) [Pubmed]
  17. The effect of theophylline on respiratory muscle contractility and fatigue. Landsberg, K.F., Vaughan, L.M., Heffner, J.E. Pharmacotherapy (1990) [Pubmed]
  18. Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue. Pistone, G., Marino, A., Leotta, C., Dell'Arte, S., Finocchiaro, G., Malaguarnera, M. Drugs & aging. (2003) [Pubmed]
  19. Fatigue, acid-base and electrolyte changes with exhaustive treadmill exercise in hemodialysis patients. Lundin, A.P., Stein, R.A., Brown, C.D., LaBelle, P., Kalman, F.S., Delano, B.G., Heneghan, W.F., Lazarus, N.A., Krasnow, N., Friedman, E.A. Nephron (1987) [Pubmed]
  20. Contractile and electrical properties of sternohyoid muscle in streptozotocin diabetic rats. McGuire, M., Dumbleton, M., MacDermott, M., Bradford, A. Clin. Exp. Pharmacol. Physiol. (2001) [Pubmed]
  21. Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4. Belluardo, N., Westerblad, H., Mudó, G., Casabona, A., Bruton, J., Caniglia, G., Pastoris, O., Grassi, F., Ibáñez, C.F. Mol. Cell. Neurosci. (2001) [Pubmed]
  22. The use of the indicator fluo-5N to measure sarcoplasmic reticulum calcium in single muscle fibres of the cane toad. Kabbara, A.A., Allen, D.G. J. Physiol. (Lond.) (2001) [Pubmed]
  23. Effect of lactate on depolarization-induced Ca(2+) release in mechanically skinned skeletal muscle fibers. Dutka, T.L., Lamb, G.D. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  24. Effect of global inspiratory muscle fatigue on ventilatory and respiratory muscle responses to CO2. Yan, S., Sliwinski, P., Gauthier, A.P., Lichros, I., Zakynthinos, S., Macklem, P.T. J. Appl. Physiol. (1993) [Pubmed]
  25. Transient improvement induced by motor fatigue in focal occupational dystonia: the handgrip test. Pesenti, A., Priori, A., Scarlato, G., Barbieri, S. Mov. Disord. (2001) [Pubmed]
  26. Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome. Plioplys, A.V. Neurology (1997) [Pubmed]
  27. Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice. Novelli, G.P., Bracciotti, G., Falsini, S. Free Radic. Biol. Med. (1990) [Pubmed]
  28. Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. Moopanar, T.R., Allen, D.G. J. Physiol. (Lond.) (2005) [Pubmed]
  29. The effect of inspiratory muscle fatigue on breathing pattern and ventilatory response to CO2. Mador, M.J., Tobin, M.J. J. Physiol. (Lond.) (1992) [Pubmed]
  30. Lactate and force production in skeletal muscle. Kristensen, M., Albertsen, J., Rentsch, M., Juel, C. J. Physiol. (Lond.) (2005) [Pubmed]
  31. The influence of celecoxib on muscle fatigue resistance and mobility in elderly patients with inflammation. Mets, T., Bautmans, I., Njemini, R., Lambert, M., Demanet, C. The American journal of geriatric pharmacotherapy. (2004) [Pubmed]
  32. Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Zhao, X., Yoshida, M., Brotto, L., Takeshima, H., Weisleder, N., Hirata, Y., Nosek, T.M., Ma, J., Brotto, M. Physiol. Genomics (2005) [Pubmed]
  33. Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fatigue indexes in humans. Thomas, C., Perrey, S., Lambert, K., Hugon, G., Mornet, D., Mercier, J. J. Appl. Physiol. (2005) [Pubmed]
  34. Effects of resistive load on the phase difference between chest and mouth flow in patients with chronic obstructive pulmonary disease. Mishima, M., Higashiya, K., Kawakami, K., Sugiura, N., Sakai, N., Hirai, T., Oku, Y., Chin, K., Ohi, M., Kuno, K. Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering. (1997) [Pubmed]
  35. Partitioning of work of breathing in mechanically ventilated COPD patients. Coussa, M.L., Guérin, C., Eissa, N.T., Corbeil, C., Chassé, M., Braidy, J., Matar, N., Milic-Emili, J. J. Appl. Physiol. (1993) [Pubmed]
  36. Glucose infusion attenuates muscle fatigue in rat plantaris muscle during prolonged indirect stimulation in situ. Karelis, A.D., Péronnet, F., Gardiner, P.F. Exp. Physiol. (2002) [Pubmed]
  37. Correlation between electromyographic spectral changes and subjective assessment of lumbar muscle fatigue in subjects without pain from the lower back. Dedering, A., Németh, G., Harms-Ringdahl, K. Clinical biomechanics (Bristol, Avon) (1999) [Pubmed]
  38. Craniomandibular disorders and masticatory muscle function. Bakke, M., Möller, E. Scandinavian journal of dental research. (1992) [Pubmed]
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