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Gene Review:

spr-5 - Protein SPR-5

Caenorhabditis elegans

Eimer, S. et al., Jarriault, S. et al.

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High impact information on spr-5

We also show that spr-5 encodes a homolog of p110b, another known member of the CoREST corepressor complex [1].
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1 [2].

Biological context of spr-5

In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-5 was identified as an extragenic suppressor of the sel-12 mutant phenotype [2].

References

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Jarriault, S., Greenwald, I. Genes Dev. (2002) [Pubmed]
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1. Eimer, S., Lakowski, B., Donhauser, R., Baumeister, R. EMBO J. (2002) [Pubmed]

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