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Gene Review:

spr-1 - Protein SPR-1

Caenorhabditis elegans

Lakowski, B. et al., Jarriault, S. et al.

Lakowski, Roelens, Jacob,

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High impact information on spr-1

Here we report the molecular identity of two spr genes, spr-1 and spr-5 [1].
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans [1].
Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression [2].
The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate [2].

Analytical, diagnostic and therapeutic context of spr-1

Sequence analysis revealed that spr-1 is an ortholog of human CoREST, a known corepressor [1].

References

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Jarriault, S., Greenwald, I. Genes Dev. (2002) [Pubmed]
CoREST-Like Complexes Regulate Chromatin Modification and Neuronal Gene Expression. Lakowski, B., Roelens, I., Jacob, S. J. Mol. Neurosci. (2006) [Pubmed]

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