Gene Review:
sel-12 - Protein SEL-12
Caenorhabditis elegans
- Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Levitan, D., Greenwald, I. Nature (1995)
- Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Jarriault, S., Greenwald, I. Genes Dev. (2002)
- Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1. Eimer, S., Lakowski, B., Donhauser, R., Baumeister, R. EMBO J. (2002)
- spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Wen, C., Levitan, D., Li, X., Greenwald, I. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Westlund, B., Parry, D., Clover, R., Basson, M., Johnson, C.D. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function. Eimer, S., Donhauser, R., Baumeister, R. Dev. Biol. (2002)
- Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Levitan, D., Greenwald, I. Development (1998)
- The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. Kitagawa, N., Shimohama, S., Oeda, T., Uemura, K., Kohno, R., Kuzuya, A., Shibasaki, H., Ishii, N. J. Biol. Chem. (2003)
- APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Levitan, D., Yu, G., St George Hyslop, P., Goutte, C. Dev. Biol. (2001)
- The presenilins and Alzheimer's disease. Hutton, M., Hardy, J. Hum. Mol. Genet. (1997)
- Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Baumeister, R., Leimer, U., Zweckbronner, I., Jakubek, C., Grünberg, J., Haass, C. Genes Funct. (1997)