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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

kal-1  -  Protein KAL-1

Caenorhabditis elegans

 
 
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High impact information on kal-1

  • We have linked individual HS modifications to two specific guidance systems, the sax-3/Robo and kal-1/Anosmin-1 systems, whose activity is dependent on different HS modifications in different cellular contexts [1].
  • In a different cellular context, heterologous C. elegans kal-1 expression causes a highly penetrant axon-misrouting phenotype [2].
  • We also show that kal-1 affects neurite outgrowth in vivo by modulating branching [3].
  • We show that kal-1 is part of a mechanism by which neurons influence migration and adhesion of epidermal cells undergoing morphogenesis during ventral enclosure and male tail formation [3].

References

  1. Differential sulfations and epimerization define heparan sulfate specificity in nervous system development. Bülow, H.E., Hobert, O. Neuron (2004) [Pubmed]
  2. Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1. Bülow, H.E., Berry, K.L., Topper, L.H., Peles, E., Hobert, O. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching. Rugarli, E.I., Di Schiavi, E., Hilliard, M.A., Arbucci, S., Ghezzi, C., Facciolli, A., Coppola, G., Ballabio, A., Bazzicalupo, P. Development (2002) [Pubmed]
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