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UBN1  -  ubinuclein 1

Homo sapiens

Synonyms: HIRA-binding protein, Protein VT4, Ubinuclein-1, Ubiquitously expressed nuclear protein, VT, ...
 
 
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Disease relevance of UBN1

  • Wilms' tumor 1-associating protein (WTAP) has been reported to be a ubiquitously expressed nuclear protein [1].
  • New VT2 variants were identified in 65 of 359 VT-producing Escherichia coli (VTEC) with newly designed primers (VT2-cm and VT2-f) and were characterized as well by restriction analysis of the amplification products obtained with another VT2-specific primer pair (VT2-e and VT2-f) [2].
  • The remaining 119 strains of O157 were from human, animal, and food sources and belonged to 16 H types other than H7 or were H-. They were VT negative and differed in their properties from O157 VTEC: generally they fermented sorbitol in 1 day, produced beta-glucuronidase, and could not be phage typed by the scheme for O157 VTEC [3].
  • All seven VT antibodies specifically immunostained the cytoplasm of islets of Langerhans cells in normal pancreas, epithelial cells of hyperplastic prostate, tumor cells of medullary thyroid carcinoma, and fibroblast-like cells of malignant melanoma [4].
  • Localization of the site of slow conduction in ventricular tachycardia was important to delineate precisely the VT critical pathway in order to guide radiofrequency and fulguration techniques [5].
 

Psychiatry related information on UBN1

  • Notably, our results indicate that VT3 and VT4 ("feel worn out" and "tired", respectively) formed a separate "fatigue" cluster more highly correlated with the mental health scale [6].
 

High impact information on UBN1

 

Biological context of UBN1

  • V = tidal volume (VT) x frequency (f), or V = inspiratory flow x (TI/TTOT, inspiratory time/total cycle time) [11].
  • CO2 inhalation increased VT with no change in f, while exercise increased both VT and f [11].
  • This in vitro study utilized a mechanical lung model that had a varying lung compliance [Cset (10-100 mL/cm H2O)] to determine the VT (measured by integrating a pneumotachograph flow signal) and corresponding minute ventilation (VE) through 14-, 16-, and 18-gauge IV catheters and small, medium, and large jet stylets [12].
  • This B29 conserved sequence (BCS) bound ubiquitously expressed nuclear protein complexes [13].
  • For all but one of the VTEC isolates, the toxin phenotype was consistent with the type of VT produced in vivo and found in the corresponding stool samples [14].
 

Anatomical context of UBN1

  • Studies of murine T cell receptor genes indicate that the VT beta repertoire, in contrast to the large VT alpha, VH, and VK repertoires, is limited to approximately 21 genes [15].
  • Direct PCR analysis of stools detected VT genes in only 11 of 20 VT-positive stool samples suggesting that the Vero cell cytotoxicity assay is more sensitive in diagnosing VTEC infection [14].
 

Associations of UBN1 with chemical compounds

 

Other interactions of UBN1

 

Analytical, diagnostic and therapeutic context of UBN1

  • The extended PCR-RFLP typing method is a useful tool to identify less-virulent VTEC isolates and for VT genotyping in epidemiological studies with non-O157 strains [2].
  • The remaining three samples were positive for VT genes by PCR but VTEC were not isolated [20].
  • Application of real-time PCR and RT-PCR assays for the detection and quantitation of VT 1 and VT 2 toxin genes in E. coli O157:H7 [21].
  • None of the food samples contained VT-producing E. coli O157 when tested by a combination of VT probe tests and colony immunoblotting with commercially available anti-O157 serum [22].

References

  1. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Horiuchi, K., Umetani, M., Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, P.C., Housman, D.E., Hamakubo, T., Kodama, T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Identification of new verocytotoxin type 2 variant B-subunit genes in human and animal Escherichia coli isolates. Piérard, D., Muyldermans, G., Moriau, L., Stevens, D., Lauwers, S. J. Clin. Microbiol. (1998) [Pubmed]
  3. Hybridization of strains of Escherichia coli O157 with probes derived from the eaeA gene of enteropathogenic E. coli and the eaeA homolog from a Vero cytotoxin-producing strain of E. coli O157. Willshaw, G.A., Scotland, S.M., Smith, H.R., Cheasty, T., Thomas, A., Rowe, B. J. Clin. Microbiol. (1994) [Pubmed]
  4. Characterization of Anti-TIMP-1 Monoclonal Antibodies for Immunohistochemical Localization in Formalin-fixed, Paraffin-embedded Tissue. Sorensen, I.V., Fenger, C., Winther, H., Foged, N.T., Lademann, U., Brünner, N., Usher, P.A. J. Histochem. Cytochem. (2006) [Pubmed]
  5. The ablative techniques from surgery to catheter ablation in the treatment of cardiac arrhythmias : a 20 year experience. Fontaine, G. Acta cardiologica. (1995) [Pubmed]
  6. SF-36 health survey: tests of data quality, scaling assumptions, and reliability in a community sample of Chinese Americans. Chang, D.F., Chun, C.A., Takeuchi, D.T., Shen, H. Medical care. (2000) [Pubmed]
  7. The T-cell receptor mediating restrictive recognition of antigen. Cohn, M. Cell (1983) [Pubmed]
  8. The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. Rafalska, I., Zhang, Z., Benderska, N., Wolff, H., Hartmann, A.M., Brack-Werner, R., Stamm, S. Hum. Mol. Genet. (2004) [Pubmed]
  9. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. Kiat, L.S., Hui, K.M., Gopalan, G. J. Biol. Chem. (2002) [Pubmed]
  10. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. Zhou, H.J., Wong, C.M., Chen, J.H., Qiang, B.Q., Yuan, J.G., Jin, D.Y. J. Biol. Chem. (2001) [Pubmed]
  11. Patterns of ventilation in postoperative and acutely ill patients. Askanazi, J., Silverberg, P.A., Hyman, A.I., Rosenbaum, S.H., Foster, R., Kinney, J.M. Crit. Care Med. (1979) [Pubmed]
  12. Can an anesthesia machine flush valve provide for effective jet ventilation? Gaughan, S.D., Benumof, J.L., Ozaki, G.T. Anesth. Analg. (1993) [Pubmed]
  13. A conserved sequence upstream of the B29 (Ig beta, CD79b) gene interacts with YY1. Patrone, L., Henson, S.E., Wall, R., Malone, C.S. Mol. Biol. Rep. (2004) [Pubmed]
  14. Pheno-genotyping of verotoxin 2 (VT2)-producing Escherichia coli causing haemorrhagic colitis and haemolytic uraemic syndrome by direct analysis of patients' stools. Caprioli, A., Luzzi, I., Gianviti, A., Russmann, H., Karch, H. J. Med. Microbiol. (1995) [Pubmed]
  15. A variable region gene subfamily encoding T cell receptor beta-chains is selectively conserved among mammals. Marche, P.N., Kindt, T.J. J. Immunol. (1986) [Pubmed]
  16. A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level. Ganapati, U., Gupta, S., Radha, V., Sudhakar, C., Manogaran, P.S., Swarup, G. Exp. Cell Res. (2001) [Pubmed]
  17. Applications of DNA probes for Vero cytotoxin-producing Escherichia coli. Smith, H.R., Willshaw, G.A., Thomas, A., Rowe, B. J. Hosp. Infect. (1991) [Pubmed]
  18. Verotoxin-producing Escherichia coli--an environment-induced emerging zoonosis in and around Calcutta. Chattopadhyay, U.K., Dutta, S., Deb, A., Pal, D. International journal of environmental health research. (2001) [Pubmed]
  19. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Lerdrup, M., Holmberg, C., Dietrich, N., Shaulian, E., Herdegen, T., Jäättelä, M., Kallunki, T. Biochim. Biophys. Acta (2005) [Pubmed]
  20. The detection of Vero cytotoxin-producing Escherichia coli and Shigella dysenteriae type 1 in faecal specimens using polymerase chain reaction gene amplification. Thomas, A., Jiggle, B., Smith, H.R., Rowe, B. Lett. Appl. Microbiol. (1994) [Pubmed]
  21. Application of real-time PCR and RT-PCR assays for the detection and quantitation of VT 1 and VT 2 toxin genes in E. coli O157:H7. Fitzmaurice, J., Glennon, M., Duffy, G., Sheridan, J.J., Carroll, C., Maher, M. Mol. Cell. Probes (2004) [Pubmed]
  22. Examination of raw beef products for the presence of Vero cytotoxin producing Escherichia coli, particularly those of serogroup O157. Willshaw, G.A., Smith, H.R., Roberts, D., Thirlwell, J., Cheasty, T., Rowe, B. J. Appl. Bacteriol. (1993) [Pubmed]
 
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