Disease relevance of UBN1

• Wilms' tumor 1-associating protein (WTAP) has been reported to be a ubiquitously expressed nuclear protein [1].
• New VT2 variants were identified in 65 of 359 VT-producing Escherichia coli (VTEC) with newly designed primers (VT2-cm and VT2-f) and were characterized as well by restriction analysis of the amplification products obtained with another VT2-specific primer pair (VT2-e and VT2-f) [2].
• The remaining 119 strains of O157 were from human, animal, and food sources and belonged to 16 H types other than H7 or were H-. They were VT negative and differed in their properties from O157 VTEC: generally they fermented sorbitol in 1 day, produced beta-glucuronidase, and could not be phage typed by the scheme for O157 VTEC [3].
• All seven VT antibodies specifically immunostained the cytoplasm of islets of Langerhans cells in normal pancreas, epithelial cells of hyperplastic prostate, tumor cells of medullary thyroid carcinoma, and fibroblast-like cells of malignant melanoma [4].
• Localization of the site of slow conduction in ventricular tachycardia was important to delineate precisely the VT critical pathway in order to guide radiofrequency and fulguration techniques [5].

Psychiatry related information on UBN1

• Notably, our results indicate that VT3 and VT4 ("feel worn out" and "tired", respectively) formed a separate "fatigue" cluster more highly correlated with the mental health scale [6].

High impact information on UBN1

• The repertoire is derived by somatic mutation of all germ-line VT genes specifying anti-RF (Model IA, Table 3 and Figure 9) [7].
• A single germ-line VT locus specifying anti-allele-specific recognition of species R encodes both the anti-R and the anti-X combining sites [7].
• YT521-B is a ubiquitously expressed nuclear protein that changes alternative splice site usage in a concentration dependent manner [8].
• AIP is a ubiquitously expressed nuclear protein that interacts specifically with human Aurora-A in vivo [9].
• HCLP-1 is a ubiquitously expressed nuclear protein which is composed almost entirely of a six-bladed beta-propeller [10].

Biological context of UBN1

• V = tidal volume (VT) x frequency (f), or V = inspiratory flow x (TI/TTOT, inspiratory time/total cycle time) [11].
• CO2 inhalation increased VT with no change in f, while exercise increased both VT and f [11].
• This in vitro study utilized a mechanical lung model that had a varying lung compliance [Cset (10-100 mL/cm H2O)] to determine the VT (measured by integrating a pneumotachograph flow signal) and corresponding minute ventilation (VE) through 14-, 16-, and 18-gauge IV catheters and small, medium, and large jet stylets [12].
• This B29 conserved sequence (BCS) bound ubiquitously expressed nuclear protein complexes [13].
• For all but one of the VTEC isolates, the toxin phenotype was consistent with the type of VT produced in vivo and found in the corresponding stool samples [14].

Anatomical context of UBN1

• Studies of murine T cell receptor genes indicate that the VT beta repertoire, in contrast to the large VT alpha, VH, and VK repertoires, is limited to approximately 21 genes [15].
• Direct PCR analysis of stools detected VT genes in only 11 of 20 VT-positive stool samples suggesting that the Vero cell cytotoxicity assay is more sensitive in diagnosing VTEC infection [14].

Associations of UBN1 with chemical compounds

• PTP-S2 is a ubiquitously expressed nuclear protein tyrosine phosphatase which shows increased expression upon mitogenic stimulation in a variety of cells in vitro and in vivo [16].
• Measurements were made of O2 consumption, CO2 production, V, VT, f, inspiratory flow, TI, and TTOT [11].
• The VT probes have been labelled radioactively and also non-radioactively with digoxigenin and biotin [17].
• All strains showed the presence of the VT gene by PCR tests and were uniformly sensitive to common antibiotics except tetracycline, cephalexin, dicloxacillin, erythromycin and lincomycin [18].

Other interactions of UBN1

• JDP2 is a ubiquitously expressed nuclear protein that efficiently represses the activity of the transcription factor AP-1 [19].

Analytical, diagnostic and therapeutic context of UBN1

• The extended PCR-RFLP typing method is a useful tool to identify less-virulent VTEC isolates and for VT genotyping in epidemiological studies with non-O157 strains [2].
• The remaining three samples were positive for VT genes by PCR but VTEC were not isolated [20].
• Application of real-time PCR and RT-PCR assays for the detection and quantitation of VT 1 and VT 2 toxin genes in E. coli O157:H7 [21].
• None of the food samples contained VT-producing E. coli O157 when tested by a combination of VT probe tests and colony immunoblotting with commercially available anti-O157 serum [22].

References