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Gene Review:

fbf-2 - Protein FBF-2

Caenorhabditis elegans

Lamont, L.B. et al., Walser, C.B. et al., Cho, S. et al.

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High impact information on fbf-2

Here, we show that puf-8, fbf-1 and fbf-2 also act in the soma where they negatively regulate vulvaI development [1].
This approach led to the identification of the PUF family members fbf-1 and fbf-2 (the fbfs) [2].

Biological context of fbf-2

Here, we show that the fbf-1 and fbf-2 genes are largely redundant for promoting mitosis but that they have opposite roles in fine-tuning the size of the mitotic region [3].

References

Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development. Walser, C.B., Battu, G., Hoier, E.F., Hajnal, A. Development (2006) [Pubmed]
The C. elegans Glycopeptide Hormone Receptor Ortholog, FSHR-1, Regulates Germline Differentiation and Survival. Cho, S., Rogers, K.W., Fay, D.S. Curr. Biol. (2007) [Pubmed]
FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Lamont, L.B., Crittenden, S.L., Bernstein, D., Wickens, M., Kimble, J. Dev. Cell (2004) [Pubmed]

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