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Gene Review:

fbf-1 - Protein FBF-1

Caenorhabditis elegans

Walser, C.B. et al., Bachorik, J.L. et al., Crittenden, S.L. et al., Lamont, L.B. et al., Thompson, B.E. et al.

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High impact information on fbf-1

Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, germline proliferation is initially normal, but stem cells are not maintained [1].
Therefore, puf-8 and fbf-1 act redundantly to control this decision [2].
Epistasis analyses place puf-8 and fbf-1 upstream of fog-2, a gene near the top of the germ-line sex determination pathway [2].
PUF-8 acts cell-autonomously in the vulval cells to limit their temporal competence to respond to the extrinsic patterning signals. fbf-1 and fbf-2, however, redundantly inhibit primary vulval cell fate specification in two distinct pathways acting in the soma and in the germline [3].
Whereas fbf-1 fbf-2 double mutants make approximately 120 germ cells, fog-1; fbf-1 fbf-2 triple mutants make only approximately 10 germ cells [4].

Biological context of fbf-1

Here, we show that the fbf-1 and fbf-2 genes are largely redundant for promoting mitosis but that they have opposite roles in fine-tuning the size of the mitotic region [5].

References

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. Crittenden, S.L., Bernstein, D.S., Bachorik, J.L., Thompson, B.E., Gallegos, M., Petcherski, A.G., Moulder, G., Barstead, R., Wickens, M., Kimble, J. Nature (2002) [Pubmed]
Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. Bachorik, J.L., Kimble, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development. Walser, C.B., Battu, G., Hoier, E.F., Hajnal, A. Development (2006) [Pubmed]
Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB. Thompson, B.E., Bernstein, D.S., Bachorik, J.L., Petcherski, A.G., Wickens, M., Kimble, J. Development (2005) [Pubmed]
FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Lamont, L.B., Crittenden, S.L., Bernstein, D., Wickens, M., Kimble, J. Dev. Cell (2004) [Pubmed]

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