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Gene Review

puf-8  -  Protein PUF-8

Caenorhabditis elegans

 
 
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High impact information on puf-8

  • Therefore, puf-8 and fbf-1 act redundantly to control this decision [1].
  • Most puf-8 mutant hermaphrodites make both sperm and oocytes and are self-fertile, but some make a vast excess of sperm and fail to switch into oogenesis [1].
  • Here, we show that puf-8, fbf-1 and fbf-2 also act in the soma where they negatively regulate vulvaI development [2].
  • Loss-of-function mutations in puf-8 cause ectopic vulval differentiation when combined with mutations in negative regulators of the EGFR/RAS/MAPK pathway and suppress the vulvaless phenotype caused by mutations that reduce EGFR/RAS/MAPK signalling [2].
  • Here, we show that PUF-8, the C. elegans PUF most related to PUMILIO, performs a different function in germ cells that have begun meiosis: in primary spermatocytes, puf-8 is required to maintain meiosis and prevent the return to mitosis [3].

References

 
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