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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

snr-3  -  Protein SNR-3

Caenorhabditis elegans

 
 
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Disease relevance of snr-3

  • Polyclonal antibodies against Hprp3p were generated with His-tagged Hprp3p over-produced in Escherichia coli . This splicing factor can co-immunoprecipitate with U4, U6 and U5 snRNAs, suggesting that it is present in the U4/U6.U5 tri-snRNP [1].
 

High impact information on snr-3

  • Several lines of evidence indicate that the SL RNP proteins function by participating in a trans-splicing specific network of protein protein interactions analogous to the U1 snRNP SF1/BBP U2AF complex that comprises the cross-intron bridge in cis-splicing [2].
  • In HeLa cells, U5-116kD is located in the nucleus and colocalizes with snRNP-containing subnuclear structures referred to as speckles [3].
  • U4/U6 snRNP is one of four essential small nuclear ribonucleoprotein (snRNP) particles (U1, U2, U5 and U4/U6) present in the spliceosome [1].

References

  1. Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. Wang, A., Forman-Kay, J., Luo, Y., Luo, M., Chow, Y.H., Plumb, J., Friesen, J.D., Tsui, L.C., Heng, H.H., Woolford, J.L., Hu, J. Hum. Mol. Genet. (1997) [Pubmed]
  2. New components of the spliced leader RNP required for nematode trans-splicing. Denker, J.A., Zuckerman, D.M., Maroney, P.A., Nilsen, T.W. Nature (2002) [Pubmed]
  3. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. Fabrizio, P., Laggerbauer, B., Lauber, J., Lane, W.S., Lührmann, R. EMBO J. (1997) [Pubmed]
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