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Gene Review

SmD1  -  Small ribonucleoprotein particle protein SmD1

Drosophila melanogaster

Synonyms: BcDNA:RE39488, CG10753, D1-Sm, Dmel\CG10753, Sm-D1, ...
 
 
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High impact information on snRNP69D

  • CONCLUSIONS: We have shown that Dart5-mediated methylation of Sm proteins is not essential for snRNP biogenesis [1].
  • On the basis of their apparent molecular weight and antigenicity many of these common and particle specific Drosophila snRNP proteins are remarkably conserved between Drosophila and human spliceosomes [2].
  • Immunoprecipitation studies in Drosophila S2 cells indicate that the Drosophila Lsm10 and Lsm11 orthologs (dLsm10 and dLsm11) associate with each other and with Sm B, but not with Sm D1 and D2 [3].
  • The U7 snRNP involved in histone RNA 3' end processing is related to but biochemically distinct from spliceosomal snRNPs [3].
  • We have studied how hrp45, hrp36 [a heterogenous nuclear ribonucleoprotein (hnRNP) protein], and small nuclear RNP (snRNP) proteins are distributed in the transcriptionally active loci of polytene chromosomes in C. tentans [4].
 

Biological context of snRNP69D

  • In the absence of dart5, snRNP biogenesis is surprisingly unaffected, and homozygous mutant animals are completely viable [1].
  • The histone locus body is no longer detectable with probes for the U7 snRNP after about stage 5 of oogenesis [5].

References

  1. The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance. Gonsalvez, G.B., Rajendra, T.K., Tian, L., Matera, A.G. Curr. Biol. (2006) [Pubmed]
  2. Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. Paterson, T., Beggs, J.D., Finnegan, D.J., Lührmann, R. Nucleic Acids Res. (1991) [Pubmed]
  3. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. Azzouz, T.N., Schumperli, D. RNA (2003) [Pubmed]
  4. A specific SR protein binds preferentially to the secretory protein gene transcripts in salivary glands of Chironomus tentans. Singh, O.P., Visa, N., Wieslander, L., Daneholt, B. Chromosoma (2006) [Pubmed]
  5. Nuclear bodies in the Drosophila germinal vesicle. Liu, J.L., Buszczak, M., Gall, J.G. Chromosome Res. (2006) [Pubmed]
 
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