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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Eftud2  -  elongation factor Tu GTP binding domain...

Mus musculus

Synonyms: 116 kDa U5 small nuclear ribonucleoprotein component, 116kDa, Elongation factor Tu GTP-binding domain-containing protein 2, Snrp116, U5 snRNP-specific protein, 116 kDa, ...
 
 
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High impact information on Eftud2

  • The G domain of U5-116kD/Snu114p contains the consensus sequence elements G1-G5 important for binding and hydrolyzing GTP [1].
  • Moreover, a single amino acid substitution in the G1 sequence motif of Snu114p, expected to abolish GTP-binding activity, is lethal, suggesting that GTP binding and probably GTP hydrolysis is important for the function of U5-116kD/Snu114p [1].
  • A 114 kDa protein (Snu114p) homologous to U5-116kD was identified in Saccharomyces cerevisiae and was shown to be essential for yeast cell viability [1].
  • In HeLa cells, U5-116kD is located in the nucleus and colocalizes with snRNP-containing subnuclear structures referred to as speckles [1].
  • Western blot analysis demonstrated that two Mabs 1D7 and 2B6 reacted specifically to a single protein with an approximately molecular weight of 116kDa, Mab 3G3 reacted with two LCDV proteins at molecular mass of approximately 116 and 90kDa [2].

References

  1. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. Fabrizio, P., Laggerbauer, B., Lauber, J., Lane, W.S., Lührmann, R. EMBO J. (1997) [Pubmed]
  2. Development and characterization of monoclonal antibody to the lymphocystis disease virus of Japanese flounder Paralichthys olivaceus isolated from China. Cheng, S., Zhan, W., Xing, J., Sheng, X. J. Virol. Methods (2006) [Pubmed]
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