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Gene Review

Eftud2  -  elongation factor Tu GTP binding domain...

Mus musculus

Synonyms: 116 kDa U5 small nuclear ribonucleoprotein component, 116kDa, Elongation factor Tu GTP-binding domain-containing protein 2, Snrp116, U5 snRNP-specific protein, 116 kDa, ...
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High impact information on Eftud2

  • The G domain of U5-116kD/Snu114p contains the consensus sequence elements G1-G5 important for binding and hydrolyzing GTP [1].
  • Moreover, a single amino acid substitution in the G1 sequence motif of Snu114p, expected to abolish GTP-binding activity, is lethal, suggesting that GTP binding and probably GTP hydrolysis is important for the function of U5-116kD/Snu114p [1].
  • A 114 kDa protein (Snu114p) homologous to U5-116kD was identified in Saccharomyces cerevisiae and was shown to be essential for yeast cell viability [1].
  • In HeLa cells, U5-116kD is located in the nucleus and colocalizes with snRNP-containing subnuclear structures referred to as speckles [1].
  • Western blot analysis demonstrated that two Mabs 1D7 and 2B6 reacted specifically to a single protein with an approximately molecular weight of 116kDa, Mab 3G3 reacted with two LCDV proteins at molecular mass of approximately 116 and 90kDa [2].


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