Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

nhx-2 - Protein NHX-2

Caenorhabditis elegans

Nehrke, K., McElwee, J.J. et al.

Nehrke,

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High impact information on nhx-2

In addition, we observed down-regulation of genes linked to nutrient uptake, including nhx-2 and pep-2 [1].
Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity [2].

Biological context of nhx-2

Gene inactivation of opt-2 led to a phenotype resembling that of nhx-2, although not as severe [2].

References

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. McElwee, J.J., Schuster, E., Blanc, E., Thomas, J.H., Gems, D. J. Biol. Chem. (2004) [Pubmed]
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span. Nehrke, K. J. Biol. Chem. (2003) [Pubmed]

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LOC518911	Bos taurus
nhx-6	Caenorhabditis elegans
nhx-9	Caenorhabditis elegans
nhx-3	Caenorhabditis elegans
LOC422276	Gallus gallus
LOC100488264	Xenopus (Silurana) tropicalis

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