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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Silencing

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Disease relevance of Gene Silencing


Psychiatry related information on Gene Silencing


High impact information on Gene Silencing

  • In plants, animals, and fungi, members of the Dicer family of RNase III-related enzymes process double-stranded RNA (dsRNA) to initiate small-RNA-mediated gene-silencing mechanisms [7].
  • We demonstrate that both a subtelomeric transgene and var genes are subject to reversible gene silencing [8].
  • von Hippel-Lindau (VHL) gene inactivation occurs in von Hippel-Lindau (VHL) disease [9].
  • Recent insights into gene silencing mechanisms by Polycomb group (PcG) and trithorax group (trxG) proteins reveal that the memory system involves a concerted process of chromatin modification, blocking of RNA polymerase II, and synthesis of noncoding RNA [10].
  • The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene silencing as well as aging in yeast [11].

Chemical compound and disease context of Gene Silencing


Biological context of Gene Silencing


Anatomical context of Gene Silencing


Associations of Gene Silencing with chemical compounds


Gene context of Gene Silencing


Analytical, diagnostic and therapeutic context of Gene Silencing


  1. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Lehnart, S.E., Wehrens, X.H., Reiken, S., Warrier, S., Belevych, A.E., Harvey, R.D., Richter, W., Jin, S.L., Conti, M., Marks, A.R. Cell (2005) [Pubmed]
  2. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Faili, A., Aoufouchi, S., Flatter, E., Guéranger, Q., Reynaud, C.A., Weill, J.C. Nature (2002) [Pubmed]
  3. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Cao, R., Zhang, Y. Mol. Cell (2004) [Pubmed]
  4. Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer. Raedle, J., Trojan, J., Brieger, A., Weber, N., Schäfer, D., Plotz, G., Staib-Sebler, E., Kriener, S., Lorenz, M., Zeuzem, S. Ann. Intern. Med. (2001) [Pubmed]
  5. Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. Warth, R., Barrière, H., Meneton, P., Bloch, M., Thomas, J., Tauc, M., Heitzmann, D., Romeo, E., Verrey, F., Mengual, R., Guy, N., Bendahhou, S., Lesage, F., Poujeol, P., Barhanin, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Bissonnette, J.M., Knopp, S.J. Pediatr. Res. (2006) [Pubmed]
  7. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine, T.F., Wohlschlegel, J.A., Kennedy, S., Bei, Y., Conte, D., Pang, K., Brownell, D.R., Harding, S., Mitani, S., Ruvkun, G., Yates, J.R., Mello, C.C. Cell (2006) [Pubmed]
  8. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Duraisingh, M.T., Voss, T.S., Marty, A.J., Duffy, M.F., Good, R.T., Thompson, J.K., Freitas-Junior, L.H., Scherf, A., Crabb, B.S., Cowman, A.F. Cell (2005) [Pubmed]
  9. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn, P.G., McDonald, E.R., Herman, J.G., El-Deiry, W.S. Nat. Genet. (2003) [Pubmed]
  10. Polycomb, epigenomes, and control of cell identity. Orlando, V. Cell (2003) [Pubmed]
  11. Negative control of p53 by Sir2alpha promotes cell survival under stress. Luo, J., Nikolaev, A.Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., Gu, W. Cell (2001) [Pubmed]
  12. Gene silencing in androgen-responsive prostate cancer cells from the tissue-specific prostate-specific antigen promoter. Song, J., Pang, S., Lu, Y., Yokoyama, K.K., Zheng, J.Y., Chiu, R. Cancer Res. (2004) [Pubmed]
  13. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder, S., Ghoshal, K., Datta, J., Bai, S., Dong, X., Quan, N., Plass, C., Jacob, S.T. J. Biol. Chem. (2002) [Pubmed]
  14. RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells. Xu, X.M., Wang, D., Shen, Q., Chen, Y.Q., Wang, M.H. Oncogene (2004) [Pubmed]
  15. Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells. Hanson, A.J., Nahreini, P., Andreatta, C., Yan, X.D., Prasad, K.N. Oncogene (2005) [Pubmed]
  16. siRNA targeting the leader sequence of SARS-CoV inhibits virus replication. Li, T., Zhang, Y., Fu, L., Yu, C., Li, X., Li, Y., Zhang, X., Rong, Z., Wang, Y., Ning, H., Liang, R., Chen, W., Babiuk, L.A., Chang, Z. Gene Ther. (2005) [Pubmed]
  17. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Ng, H.H., Zhang, Y., Hendrich, B., Johnson, C.A., Turner, B.M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., Bird, A. Nat. Genet. (1999) [Pubmed]
  18. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Dorer, D.R., Henikoff, S. Cell (1994) [Pubmed]
  19. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Guy, J., Hendrich, B., Holmes, M., Martin, J.E., Bird, A. Nat. Genet. (2001) [Pubmed]
  20. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Hendrich, B., Hardeland, U., Ng, H.H., Jiricny, J., Bird, A. Nature (1999) [Pubmed]
  21. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., Jenuwein, T. Nature (2001) [Pubmed]
  22. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Trumpp, A., Depew, M.J., Rubenstein, J.L., Bishop, J.M., Martin, G.R. Genes Dev. (1999) [Pubmed]
  23. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H.S., Hogan, B.L. Genes Dev. (2003) [Pubmed]
  24. Control of cytomegalovirus lytic gene expression by histone acetylation. Murphy, J.C., Fischle, W., Verdin, E., Sinclair, J.H. EMBO J. (2002) [Pubmed]
  25. Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Greenbaum, S., Zhuang, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. Xu, S., Huo, J., Tan, J.E., Lam, K.P. Mol. Cell. Biol. (2005) [Pubmed]
  27. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., De Acetis, M., Vecchione, C., Marino, G., Altruda, F., Silengo, L., Tarone, G., Lembo, G. Nat. Med. (2003) [Pubmed]
  28. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Hasty, P., Ramírez-Solis, R., Krumlauf, R., Bradley, A. Nature (1991) [Pubmed]
  29. Many paths to methyltransfer: a chronicle of convergence. Schubert, H.L., Blumenthal, R.M., Cheng, X. Trends Biochem. Sci. (2003) [Pubmed]
  30. Leaving a mark: the many footprints of the elongating RNA polymerase II. Eissenberg, J.C., Shilatifard, A. Curr. Opin. Genet. Dev. (2006) [Pubmed]
  31. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation. Cogoni, C., Irelan, J.T., Schumacher, M., Schmidhauser, T.J., Selker, E.U., Macino, G. EMBO J. (1996) [Pubmed]
  32. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee, I., Bachman, K.E., Park, B.H., Jair, K.W., Yen, R.W., Schuebel, K.E., Cui, H., Feinberg, A.P., Lengauer, C., Kinzler, K.W., Baylin, S.B., Vogelstein, B. Nature (2002) [Pubmed]
  33. The polycomb group protein EZH2 is involved in progression of prostate cancer. Varambally, S., Dhanasekaran, S.M., Zhou, M., Barrette, T.R., Kumar-Sinha, C., Sanda, M.G., Ghosh, D., Pienta, K.J., Sewalt, R.G., Otte, A.P., Rubin, M.A., Chinnaiyan, A.M. Nature (2002) [Pubmed]
  34. Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Ebert, A., Schotta, G., Lein, S., Kubicek, S., Krauss, V., Jenuwein, T., Reuter, G. Genes Dev. (2004) [Pubmed]
  35. The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae. Meijsing, S.H., Ehrenhofer-Murray, A.E. Genes Dev. (2001) [Pubmed]
  36. Conversion of a gene-specific repressor to a regional silencer. Rusché, L.N., Rine, J. Genes Dev. (2001) [Pubmed]
  37. Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Ravanat, C., Morales, M., Azorsa, D.O., Moog, S., Schuhler, S., Grunert, P., Loew, D., Van Dorsselaer, A., Cazenave, J.P., Lanza, F. Blood (1997) [Pubmed]
  38. Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. Heyman, M., Rasool, O., Borgonovo Brandter, L., Liu, Y., Grandér, D., Söderhäll, S., Gustavsson, G., Einhorn, S. J. Clin. Oncol. (1996) [Pubmed]
  39. High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector. Varela-Echavarría, A., Prorock, C.M., Ron, Y., Dougherty, J.P. J. Virol. (1993) [Pubmed]
  40. Novel mutations of the von hippel-lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear-cell type. Meyer, A.J., Hernandez, A., Florl, A.R., Enczmann, J., Gerharz, C.D., Schulz, W.A., Wernet, P., Ackermann, R. Int. J. Cancer (2000) [Pubmed]
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