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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cam-1  -  Protein CAM-1

Caenorhabditis elegans

 
 
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High impact information on cam-1

  • Overexpression and loss of cam-1 function result in reciprocal cell-migration phenotypes, indicating that levels of CAM-1 influence the final positions of migrating cells [1].
  • Here we show that the Caenorhabditis elegans gene cam-1 encodes a member of the Ror kinase family that guides migrating cells and orients the polarity of asymmetric cell divisions and axon outgrowth [1].
 

Biological context of cam-1

  • To investigate the functional requirement for CAM-1 domains in mediating cell migration, we engineered deletions that remove various domains and assessed the ability of these CAM-1 derivatives to rescue cam-1 mutant phenotypes [2].

References

  1. A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Forrester, W.C., Dell, M., Perens, E., Garriga, G. Nature (1999) [Pubmed]
  2. Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1. Kim, C., Forrester, W.C. Dev. Biol. (2003) [Pubmed]
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