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Gene Review

Ror2  -  receptor tyrosine kinase-like orphan...

Mus musculus

Synonyms: Neurotrophic tyrosine kinase, receptor-related 2, Ntrkr2, Tyrosine-protein kinase transmembrane receptor ROR2, mROR2, mRor2
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Disease relevance of Ror2

  • BACKGROUNDS: Drosophila neurospecific receptor tyrosine kinases (RTKs), Dror and Dnrk, as well as Ror1 and Ror2 RTKs, isolated from human neuroblastoma, have been identified as a structurally related novel family of RTKs (Ror-family RTKs) [1].
  • RESULTS: Both Ror2-/- and Wnt5a-/- mice exhibit dwarfism, facial abnormalities, short limbs and tails, dysplasia of lungs and genitals, and ventricular septal defects [2].

High impact information on Ror2

  • Further, we find that Ror2 is selectively expressed in the chondrocytes of all developing cartilage anlagen, where it essential during initial growth and patterning, as well as subsequently in the proliferating chondrocytes of mature growth plates, where it is required for normal expansion [3].
  • Thus, Ror2 encodes a receptor-like tyrosine kinase that is selectively expressed in, and particularly important for, the chondrocyte lineage [3].
  • The mammalian Ror family of receptor tyrosine kinases consists of two structurally related proteins, Ror1 and Ror2 [4].
  • Interestingly, mRor1/mRor2 double mutant mice show markedly enhanced skeletal abnormalities compared with mRor2 mutant mice [4].
  • Furthermore, double mutant mice also exhibit defects not observed in mRor2 mutant mice, including a sternal defect, dysplasia of the symphysis of the pubic bone, and complete transposition of the great arteries [4].

Biological context of Ror2


Anatomical context of Ror2

  • Immunocytochemical analysis indicated that Ror1 and Ror2 are highly concentrated in the growth cones of immature neurons and are present throughout the somatodendritic compartment of mature hippocampal cells [7].
  • Interestingly, at early stages, Ror1 and Ror2 exhibit similar expression patterns in the developing face, including the frontonasal process and pharyngeal arches, which are derived from cephalic neural crest cells [5].
  • At these times, Ror2 is expressed much more widely than Ror1, expression of which is largely restricted to head mesenchyme [8].
  • Ror1 and Ror2 are both expressed in derivatives of all three germ layers and in most organ systems, including the nervous, circulatory, respiratory, digestive, urogenital and skeletal systems [8].
  • Whole-mount in situ hybridization analysis showed that mRor2 was expressed in the branchial arches, heart and limb/tailbuds, in addition to the developing nervous system [9].

Associations of Ror2 with chemical compounds


Physical interactions of Ror2


Other interactions of Ror2


  1. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Oishi, I., Takeuchi, S., Hashimoto, R., Nagabukuro, A., Ueda, T., Liu, Z.J., Hatta, T., Akira, S., Matsuda, Y., Yamamura, H., Otani, H., Minami, Y. Genes Cells (1999) [Pubmed]
  2. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Oishi, I., Suzuki, H., Onishi, N., Takada, R., Kani, S., Ohkawara, B., Koshida, I., Suzuki, K., Yamada, G., Schwabe, G.C., Mundlos, S., Shibuya, H., Takada, S., Minami, Y. Genes Cells (2003) [Pubmed]
  3. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. DeChiara, T.M., Kimble, R.B., Poueymirou, W.T., Rojas, J., Masiakowski, P., Valenzuela, D.M., Yancopoulos, G.D. Nat. Genet. (2000) [Pubmed]
  4. Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Nomi, M., Oishi, I., Kani, S., Suzuki, H., Matsuda, T., Yoda, A., Kitamura, M., Itoh, K., Takeuchi, S., Takeda, K., Akira, S., Ikeya, M., Takada, S., Minami, Y. Mol. Cell. Biol. (2001) [Pubmed]
  5. Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Matsuda, T., Nomi, M., Ikeya, M., Kani, S., Oishi, I., Terashima, T., Takada, S., Minami, Y. Mech. Dev. (2001) [Pubmed]
  6. The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. Kani, S., Oishi, I., Yamamoto, H., Yoda, A., Suzuki, H., Nomachi, A., Iozumi, K., Nishita, M., Kikuchi, A., Takumi, T., Minami, Y. J. Biol. Chem. (2004) [Pubmed]
  7. Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons. Paganoni, S., Ferreira, A. J. Neurosci. Res. (2003) [Pubmed]
  8. Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Al-Shawi, R., Ashton, S.V., Underwood, C., Simons, J.P. Dev. Genes Evol. (2001) [Pubmed]
  9. Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Takeuchi, S., Takeda, K., Oishi, I., Nomi, M., Ikeya, M., Itoh, K., Tamura, S., Ueda, T., Hatta, T., Otani, H., Terashima, T., Takada, S., Yamamura, H., Akira, S., Minami, Y. Genes Cells (2000) [Pubmed]
  10. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Sammar, M., Stricker, S., Schwabe, G.C., Sieber, C., Hartung, A., Hanke, M., Oishi, I., Pohl, J., Minami, Y., Sebald, W., Mundlos, S., Knaus, P. Genes Cells (2004) [Pubmed]
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