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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-130  -  Protein UNC-130

Caenorhabditis elegans

 
 
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High impact information on unc-130

  • This fits our present finding that unc-130 cell autonomously represses unc-129 expression in the ventral body muscles [1].
  • Also, unc-130 is partially required for male tail morphogenesis and for embryogenesis [1].
  • Genetic interactions between unc-130 and other guidance genes show that several molecular pathways function in parallel to guide the ventral to dorsal migration of distal tip cells (DTCs) and axonal growth cones in C. elegans [1].
  • Three other genes specifically affect pioneer-follower relationships between early and late outgrowing axons, controlling either differentiation of a pioneer neuron (lin-11) or the ability of axons to follow a pioneer (ast-2, unc-130) [2].
 

Biological context of unc-130

  • The phenotype of unc-130 mutants closely mimics the reported effects of ectopically expressing unc-129 in both dorsal and ventral body muscles () [1].
 

Other interactions of unc-130

  • Thus the cell-specific effects of unc-130 on ventral, but not dorsal, body muscle expression of unc-129 accounts for the D/V polarity information required for UNC-129-mediated guidance [1].

References

  1. The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans. Nash, B., Colavita, A., Zheng, H., Roy, P.J., Culotti, J.G. Genes Dev. (2000) [Pubmed]
  2. Novel genes controlling ventral cord asymmetry and navigation of pioneer axons in C. elegans. Hutter, H., Wacker, I., Schmid, C., Hedgecock, E.M. Dev. Biol. (2005) [Pubmed]
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