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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lin-48  -  Protein LIN-48

Caenorhabditis elegans

 
 
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High impact information on lin-48

  • We show that lin-48 requires egl-38 for its expression in the hindgut [1].
  • We show that lin-48 encodes a C2H2 zinc-finger protein that is similar to the product of the Drosophila gene ovo and is expressed in the hindgut cells that develop abnormally in lin-48 mutants [1].
  • Although lin-48 is required for both anatomical and physiological features of the excretory duct cell, ces-2 and atf-2 mutants only exhibit anatomical defects [2].
  • Both proteins influence transactivation of a target gene, lin-48 [2].
  • First, specific differences in the regulatory sequences of lin-48 result in the presence of two redundant EGL-38 response elements in C. elegans, whereas the redundancy is absent in C. briggsae [3].

References

  1. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Johnson, A.D., Fitzsimmons, D., Hagman, J., Chamberlin, H.M. Development (2001) [Pubmed]
  2. The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans. Wang, X., Jia, H., Chamberlin, H.M. Dev. Biol. (2006) [Pubmed]
  3. Evolution of regulatory elements producing a conserved gene expression pattern in Caenorhabditis. Wang, X., Greenberg, J.F., Chamberlin, H.M. Evol. Dev. (2004) [Pubmed]
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