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Gene Review

lin-48  -  Protein LIN-48

Caenorhabditis elegans

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High impact information on lin-48

  • We show that lin-48 requires egl-38 for its expression in the hindgut [1].
  • We show that lin-48 encodes a C2H2 zinc-finger protein that is similar to the product of the Drosophila gene ovo and is expressed in the hindgut cells that develop abnormally in lin-48 mutants [1].
  • Although lin-48 is required for both anatomical and physiological features of the excretory duct cell, ces-2 and atf-2 mutants only exhibit anatomical defects [2].
  • Both proteins influence transactivation of a target gene, lin-48 [2].
  • First, specific differences in the regulatory sequences of lin-48 result in the presence of two redundant EGL-38 response elements in C. elegans, whereas the redundancy is absent in C. briggsae [3].


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