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Gene Review

ovo  -  CG6824 gene product from transcript CG6824-RE

Drosophila melanogaster

Synonyms: CG15467, CG6824, Dmel\CG6824, Fs(1)K1103, Fs(1)K1237, ...
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Disease relevance of ovo


High impact information on ovo

  • Conversely, Wingless promotes the smooth cell fate through the transcriptional repression of svb by the bipartite nuclear factor Armadillo/dTcf [1].
  • The DER pathway promotes denticle formation by activating svb expression [1].
  • Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female germline development and svb for epidermal morphogenesis [1].
  • The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice [4].
  • Mutations at the ovo locus result in a defective female germ line [5].

Biological context of ovo


Anatomical context of ovo

  • By using various ovo-lacZ reporter genes, we determined that the long Ovo isoforms starting at methionine M1, present in transcripts ovo alpha, are expressed at low levels only in mature oocytes [10].
  • Our examination of ovo null mutant organelles demonstrate that it is required for the differentiation of XX germ cells during larval gonial stages, in addition to its known role in maintaining germ cell numbers [11].
  • We have mapped the ovo locus to position 4E1-2 of the salivary gland X chromosome by using a set of cytologically visible deletions [5].
  • Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis [12].
  • Essentially the same rules for siRNA sequence preference were found applicable to DNA-based RNAi in mammalian cells and in ovo RNAi using chick embryos [13].

Associations of ovo with chemical compounds


Physical interactions of ovo

  • Interestingly, the strongest OVO-binding site is very near the otu transcription start, where basal transcriptional complexes must function [8].

Regulatory relationships of ovo


Other interactions of ovo


Analytical, diagnostic and therapeutic context of ovo

  • In ovo electroporation on E2 chick brain with the eucaryotic expression vector that encodes chick Pax-5 cDNA was used [19].
  • By using various genomic probes for in situ hybridization to wild type and mutant embryos, we show that ovo indeed shares most of its coding sequences with svb. svb expression is detected early in the presumptive head region and later in each segment [20].
  • Genetic mapping experiments and interspecific complementation tests indicate that this difference is caused, in its entirety, by evolution at the ovo/shaven-baby locus [21].


  1. ovo/svb integrates Wingless and DER pathways to control epidermis differentiation. Payre, F., Vincent, A., Carreno, S. Nature (1999) [Pubmed]
  2. Developmental analysis of the ovarian tumor gene during Drosophila oogenesis. Rodesch, C., Geyer, P.K., Patton, J.S., Bae, E., Nagoshi, R.N. Genetics (1995) [Pubmed]
  3. Protein determinants of insertional specificity for the Drosophila gypsy retrovirus. Labrador, M., Corces, V.G. Genetics (2001) [Pubmed]
  4. The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Dai, X., Schonbaum, C., Degenstein, L., Bai, W., Mahowald, A., Fuchs, E. Genes Dev. (1998) [Pubmed]
  5. The ovo locus is required for sex-specific germ line maintenance in Drosophila. Oliver, B., Perrimon, N., Mahowald, A.P. Genes Dev. (1987) [Pubmed]
  6. The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline. Nagoshi, R.N., Patton, J.S., Bae, E., Geyer, P.K. Development (1995) [Pubmed]
  7. The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination. Pauli, D., Oliver, B., Mahowald, A.P. Development (1993) [Pubmed]
  8. Drosophila OVO regulates ovarian tumor transcription by binding unusually near the transcription start site. Lü, J., Oliver, B. Development (2001) [Pubmed]
  9. The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development. Mével-Ninio, M., Terracol, R., Kafatos, F.C. EMBO J. (1991) [Pubmed]
  10. The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons. Mével-Ninio, M., Fouilloux, E., Guénal, I., Vincent, A. Development (1996) [Pubmed]
  11. Regulatory and functional interactions between ovarian tumor and ovo during Drosophila oogenesis. Hinson, S., Pettus, J., Nagoshi, R.N. Mech. Dev. (1999) [Pubmed]
  12. Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis. Masu, Y., Ikeda, S., Okuda-Ashitaka, E., Sato, E., Ito, S. FEBS Lett. (1998) [Pubmed]
  13. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Ui-Tei, K., Naito, Y., Takahashi, F., Haraguchi, T., Ohki-Hamazaki, H., Juni, A., Ueda, R., Saigo, K. Nucleic Acids Res. (2004) [Pubmed]
  14. Genetic evidence that the ovo locus is involved in Drosophila germ line sex determination. Oliver, B., Pauli, D., Mahowald, A.P. Genetics (1990) [Pubmed]
  15. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Johnson, A.D., Fitzsimmons, D., Hagman, J., Chamberlin, H.M. Development (2001) [Pubmed]
  16. Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Walters, J.W., Muñoz, C., Paaby, A.B., Dinardo, S. Dev. Biol. (2005) [Pubmed]
  17. stand still, a Drosophila gene involved in the female germline for proper survival, sex determination and differentiation. Pennetta, G., Pauli, D. Genetics (1997) [Pubmed]
  18. Ectopic expression of lunatic Fringe leads to downregulation of Serrate-1 in the developing chick neural tube; analysis using in ovo electroporation transfection technique. Sakamoto, K., Nakamura, H., Takagi, M., Takeda, S., Katsube, K. FEBS Lett. (1998) [Pubmed]
  19. Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity. Funahashi, J., Okafuji, T., Ohuchi, H., Noji, S., Tanaka, H., Nakamura, H. Dev. Growth Differ. (1999) [Pubmed]
  20. ovo, a Drosophila gene required for ovarian development, is specifically expressed in the germline and shares most of its coding sequences with shavenbaby, a gene involved in embryo patterning. Mével-Ninio, M., Terracol, R., Salles, C., Vincent, A., Payre, F. Mech. Dev. (1995) [Pubmed]
  21. Divergence of larval morphology between Drosophila sechellia and its sibling species caused by cis-regulatory evolution of ovo/shaven-baby. Sucena, E., Stern, D.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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