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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tbb-2  -  Protein TBB-2

Caenorhabditis elegans

 
 
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High impact information on tbb-2

  • Our identification of two recessive, complementing alleles of a beta-tubulin that disrupt nuclear-centrosome centration and rotation in the early embryo originally suggested that this tubulin, tbb-2, has specialized functions [1].
  • Expression of the beta 2-tubulin gene is developmentally regulated and the message is found predominantly in adult male worms, whereas the beta 1-tubulin gene is expressed in microfilariae and approximately equal levels of the transcript are found in male and female adult worms [2].
  • Southern hybridization analyses show that the beta 2-tubulin sequence exists as a single copy gene within the B. pahangi genome [2].

References

  1. Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo. Wright, A.J., Hunter, C.P. Mol. Biol. Cell (2003) [Pubmed]
  2. Identification of a novel Brugia pahangi beta-tubulin gene (beta 2) and a 22-nucleotide spliced leader sequence on beta 1-tubulin mRNA. Guénette, S., Prichard, R.K., Matlashewski, G. Mol. Biochem. Parasitol. (1992) [Pubmed]
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