Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

xbp-1 - Protein XBP-1

Caenorhabditis elegans

Shen, X. et al., Kapulkin, V. et al., Shen, X. et al.

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High impact information on xbp-1

C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress [1].

Biological context of xbp-1

Knockdown by RNA interference of 9 known or predicted ER chaperones induced hsp-4 upregulation via the ire-1/xbp-1 signaling cascade employed in the unfolded protein response [2].

Other interactions of xbp-1

Although ire-1 and xbp-1 together regulate transcription of most i-UPR genes, they are each required for expression of nonoverlapping sets of c-UPR genes, suggesting that they have distinct functions [3].

References

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Shen, X., Ellis, R.E., Lee, K., Liu, C.Y., Yang, K., Solomon, A., Yoshida, H., Morimoto, R., Kurnit, D.M., Mori, K., Kaufman, R.J. Cell (2001) [Pubmed]
Compensatory regulation among ER chaperones in C. elegans. Kapulkin, V., Hiester, B.G., Link, C.D. FEBS Lett. (2005) [Pubmed]
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen, X., Ellis, R.E., Sakaki, K., Kaufman, R.J. PLoS Genet. (2005) [Pubmed]

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