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Gene Review:

ire-1 - Protein IRE-1

Caenorhabditis elegans

Kapulkin, V. et al., Shen, X. et al., Shen, X. et al., Uccelletti, D. et al.

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High impact information on ire-1

We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis [1].
C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress [1].
Up-regulation of uda-1 did not occur in ire-1-deficient mutants, demonstrating the role of this ER stress sensor in this event [2].

Biological context of ire-1

Knockdown by RNA interference of 9 known or predicted ER chaperones induced hsp-4 upregulation via the ire-1/xbp-1 signaling cascade employed in the unfolded protein response [3].

Other interactions of ire-1

Although ire-1 and xbp-1 together regulate transcription of most i-UPR genes, they are each required for expression of nonoverlapping sets of c-UPR genes, suggesting that they have distinct functions [4].

References

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Shen, X., Ellis, R.E., Lee, K., Liu, C.Y., Yang, K., Solomon, A., Yoshida, H., Morimoto, R., Kurnit, D.M., Mori, K., Kaufman, R.J. Cell (2001) [Pubmed]
ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. Uccelletti, D., O'Callaghan, C., Berninsone, P., Zemtseva, I., Abeijon, C., Hirschberg, C.B. J. Biol. Chem. (2004) [Pubmed]
Compensatory regulation among ER chaperones in C. elegans. Kapulkin, V., Hiester, B.G., Link, C.D. FEBS Lett. (2005) [Pubmed]
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen, X., Ellis, R.E., Sakaki, K., Kaufman, R.J. PLoS Genet. (2005) [Pubmed]

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AgaP_AGAP004176	Anopheles gambiae str. PEST
LOC524719	Bos taurus
ERN1	Canis lupus familiaris
ern2	Danio rerio
Ire1	Drosophila melanogaster
LOC417414	Gallus gallus
ERN1	Homo sapiens
ERN1	Macaca mulatta
Ern1	Mus musculus
ERN1	Pan troglodytes
Ern1	Rattus norvegicus
ern2	Xenopus (Silurana) tropicalis

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