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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cyk-3  -  Protein CYK-3

Caenorhabditis elegans

 
 
 
 
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High impact information on cyk-3

  • The cyk-3 gene has been identified and found to encode a ubiquitin C-terminal hydrolase that is active against model substrates [1].
  • We have further analyzed the cyk-3 mutant phenotype and have found that cyk-3 mutant embryos fail to properly polarize the actin cytoskeleton and fail to segregate germline determinants [1].
  • However, we have found that cyk-3 mutant embryos are intrinsically defective in osmotic regulation and that the cytokinesis defects can be partially rescued by providing osmotic support [1].

References

  1. A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo. Kaitna, S., Schnabel, H., Schnabel, R., Hyman, A.A., Glotzer, M. J. Cell. Sci. (2002) [Pubmed]
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