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ceeh-2  -  Protein CEEH-2

Caenorhabditis elegans

 
 
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Disease relevance of hydrolase

  • Two genes from Caenorhabditis elegans and Saccharomyces cerevisiae, coding for enzymes homologous to the Nudix hydrolase family of nucleotide pyrophosphatases, have been cloned and expressed in Escherichia coli [1].
  • Analysis of the results of this study suggests that certain acid hydrolase enzymes could be involved in the elimination of B. pahangi in refractory strains of Ae. aegypti and could be used to monitor biochemical changes in response to filarial nematode infections in certain mosquito populations [2].
 

High impact information on hydrolase

 

Biological context of hydrolase

  • Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio [7].
  • Protein domain of unknown function DUF1023 is an alpha/beta hydrolase [8].
 

Associations of hydrolase with chemical compounds

 

Other interactions of hydrolase

 

Analytical, diagnostic and therapeutic context of hydrolase

References

  1. Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily. Xu, W., Dunn, C.A., Bessman, M.J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Comparative development of Brugia pahangi and variation in acid hydrolase enzyme titers in. Rodriguez, P.H., Larson, G.A., Lazaro, C.A., Castillon, R., Nasr-Schirf, D. J. Am. Mosq. Control Assoc. (2000) [Pubmed]
  3. Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis. Abdelghany, H.M., Bailey, S., Blackburn, G.M., Rafferty, J.B., McLennan, A.G. J. Biol. Chem. (2003) [Pubmed]
  4. The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid alpha /beta hydrolase. Huhtinen, K., O'Byrne, J., Lindquist, P.J., Contreras, J.A., Alexson, S.E. J. Biol. Chem. (2002) [Pubmed]
  5. The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. Cartwright, J.L., Gasmi, L., Spiller, D.G., McLennan, A.G. J. Biol. Chem. (2000) [Pubmed]
  6. A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo. Kaitna, S., Schnabel, H., Schnabel, R., Hyman, A.A., Glotzer, M. J. Cell. Sci. (2002) [Pubmed]
  7. The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms. Bailey, S., Sedelnikova, S.E., Blackburn, G.M., Abdelghany, H.M., Baker, P.J., McLennan, A.G., Rafferty, J.B. Structure (Camb.) (2002) [Pubmed]
  8. Protein domain of unknown function DUF1023 is an alpha/beta hydrolase. Zheng, M., Ginalski, K., Rychlewski, L., Grishin, N.V. Proteins (2005) [Pubmed]
  9. Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. Guranowski, A., Starzyńska, E., McLennan, A.G., Baraniak, J., Stec, W.J. Biochem. J. (2003) [Pubmed]
  10. The localization and some properties of the acetylsalicylic acid O-deacetylases of Ascaris lumbricoides var suum and Moniezia expansa. Douch, P.G. Xenobiotica (1978) [Pubmed]
  11. The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase. AbdelRaheim, S.R., McLennan, A.G. BMC Biochem. (2002) [Pubmed]
  12. Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. Abdelghany, H.M., Gasmi, L., Cartwright, J.L., Bailey, S., Rafferty, J.B., McLennan, A.G. Biochim. Biophys. Acta (2001) [Pubmed]
 
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