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Gene Review:

let-756 - Protein LET-756

Caenorhabditis elegans

Popovici, C. et al., Szewczyk, N.J. et al.

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High impact information on let-756

This activation is not suppressed by mutation in either of the known genes encoding FGF ligands (egl-17 or let-756) but is well suppressed when both are mutated, indicating that either ligand is sufficient and at least one is necessary for FGFR activation [1].
LET-756 deleted in its core region was no longer able to rescue the lethal phenotype of a let-756 null mutant, and only chimeras containing the cores of FGFs 9, 16, and 20 showed rescue capacity [2].

Other interactions of let-756

In non-vertebrates, six FGF genes have been identified in Ciona intestinalis, three in Drosophila melanogaster, and two (let-756 and egl-17) in Caenorhabditis elegans [2].

References

Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans. Szewczyk, N.J., Jacobson, L.A. EMBO J. (2003) [Pubmed]
Functional phylogeny relates LET-756 to fibroblast growth factor 9. Popovici, C., Conchonaud, F., Birnbaum, D., Roubin, R. J. Biol. Chem. (2004) [Pubmed]

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