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Gene Review

cyk-1  -  Protein CYK-1

Caenorhabditis elegans

 
 
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High impact information on cyk-1

  • The cytokinesis defect appears to be late in the cell cycle because transient cleavage furrows initiate at the proper location, but regress before the division is complete [1].
  • Cleavage furrows regress after completion of mitosis in cyk-1 mutants, leaving multiple nuclei in a single cell [2].
  • Positional cloning and sequence analysis of the cyk-1 gene reveal that it encodes an FH protein, a newly defined family of proteins that appear to interact with the cytoskeleton during cytokinesis and in the regulation of cell polarity [2].

References

  1. AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos. Schumacher, J.M., Golden, A., Donovan, P.J. J. Cell Biol. (1998) [Pubmed]
  2. cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis. Swan, K.A., Severson, A.F., Carter, J.C., Martin, P.R., Schnabel, H., Schnabel, R., Bowerman, B. J. Cell. Sci. (1998) [Pubmed]
 
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