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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-36  -  Protein UNC-36

Caenorhabditis elegans

 
 
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High impact information on unc-36

  • Mutations in the unc-36 and eat-4 genes are partially neuroprotective, which indicates that endogenous signaling modulates the severity of the neurotoxic effects of Galphas [1].
  • Moreover, the unc-36 gene appears to be required in the same cells as unc-2 for control of the same behaviors [2].
  • The 35 lethals studied were derived from 875 screened F1's. Among these lethals there were (1) at least two unc-36 duplications, (2) at least four translocations, (3) at least six deficiencies of chromosome V (these delete about 90% of the unc-60 to unc-42 region) and (4) several unanalyzed rearrangements [3].
  • Interestingly, while egl-19 mutations resulted in similar reductions in calcium influx at all stimulus strengths, unc-36 mutations preferentially affected responses to smaller depolarizations [4].

References

  1. G alphas-induced neurodegeneration in Caenorhabditis elegans. Berger, A.J., Hart, A.C., Kaplan, J.M. J. Neurosci. (1998) [Pubmed]
  2. Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Schafer, W.R., Sanchez, B.M., Kenyon, C.J. Genetics (1996) [Pubmed]
  3. Mutagenesis in Caenorhabditis elegans. II. A spectrum of mutational events induced with 1500 r of gamma-radiation. Rosenbluth, R.E., Cuddeford, C., Baillie, D.L. Genetics (1985) [Pubmed]
  4. Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons. Frøkjaer-Jensen, C., Kindt, K.S., Kerr, R.A., Suzuki, H., Melnik-Martinez, K., Gerstbreih, B., Driscol, M., Schafer, W.R. J. Neurobiol. (2006) [Pubmed]
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