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Gene Review

unc-2  -  Protein UNC-2

Caenorhabditis elegans

 
 
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Disease relevance of unc-2

 

High impact information on unc-2

  • In addition, unc-2 mutants displayed behaviours similar to those induced by serotonin treatment [2].
  • Here we report that the Caenorhabditis elegans gene unc-2 is required for adaptation to two neurotransmitters, dopamine and serotonin [2].
  • In mutants lacking a voltage-dependent calcium channel (unc-2) or a vesicular glutamate transporter (VGLUT; eat-4), the abundance of GLR-1 in the ventral nerve cord was increased [3].
  • In mutants carrying loss-of-function alleles of the calcium channel gene unc-2, the touch receptor neuron AVM and the interneuron SDQR often migrated inappropriately, leading to misplacement of their cell bodies [4].
  • By genetic dissection of the lethargic mutant phenotype of unc-2, we have established an epistasis pathway showing that UNC-2 function antagonizes a transforming growth factor (TGF)-beta pathway influencing movement rate [5].
 

Anatomical context of unc-2

  • Using an unc-2 promoter-tagged green fluorescent protein construct, we show that unc-2 is primarily expressed in motor neurons, several subsets of sensory neurons, and the HSN and VC neurons that control egg laying [6].
 

Other interactions of unc-2

  • Moreover, the unc-36 gene appears to be required in the same cells as unc-2 for control of the same behaviors [1].
 

Analytical, diagnostic and therapeutic context of unc-2

  • Sequence analysis of the unc-2 alleles shows that e55, ra605, ra606, ra609, and ra610 all are predicted to prematurely terminate and greatly reduce or eliminate unc-2 function [6].

References

  1. Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Schafer, W.R., Sanchez, B.M., Kenyon, C.J. Genetics (1996) [Pubmed]
  2. A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Schafer, W.R., Kenyon, C.J. Nature (1995) [Pubmed]
  3. Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade. Grunwald, M.E., Mellem, J.E., Strutz, N., Maricq, A.V., Kaplan, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Voltage-gated calcium channels direct neuronal migration in Caenorhabditis elegans. Tam, T., Mathews, E., Snutch, T.P., Schafer, W.R. Dev. Biol. (2000) [Pubmed]
  5. The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase. Estevez, M., Estevez, A.O., Cowie, R.H., Gardner, K.L. J. Neurochem. (2004) [Pubmed]
  6. Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties. Mathews, E.A., García, E., Santi, C.M., Mullen, G.P., Thacker, C., Moerman, D.G., Snutch, T.P. J. Neurosci. (2003) [Pubmed]
 
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