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Gene Review

unc-60  -  Protein UNC-60

Caenorhabditis elegans

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High impact information on unc-60

  • In Caenorhabditis elegans, UNC-60A and UNC-60B, nonmuscle and muscle isoforms of actin depolymerizing factor (ADF)/cofilin, are expressed by alternative splicing of unc-60 and regulate distinct actin-dependent developmental processes [1].
  • Regardless of these various molecular phenotypes, actin was not properly assembled into embryonic myofibrils in all unc-60 mutants to similar extents [2].
  • The Caenorhabditis elegans unc-60 gene encodes two functionally distinct isoforms of ADF/cofilin that are implicated in myofibril assembly [2].
  • We found that all homozygous viable unc-60 mutations resided in the unc-60B coding region, indicating that UNC-60B is responsible for the Unc-60 phenotype [2].
  • The Caenorhabditis elegans unc-60 gene encodes two actin depolymerizing factor/cofilin proteins which are implicated in the regulation of actin filament assembly in body wall muscle [3].

Biological context of unc-60

  • The 35 lethals studied were derived from 875 screened F1's. Among these lethals there were (1) at least two unc-36 duplications, (2) at least four translocations, (3) at least six deficiencies of chromosome V (these delete about 90% of the unc-60 to unc-42 region) and (4) several unanalyzed rearrangements [4].
  • The Caenorhabditis elegans unc-60 gene generates two ADF/cofilins, UNC-60A and UNC-60B, by alternative splicing [5].
  • Regarding unc-60 itself, we compared the effect of ten alleles (including five isolated during this study) on hermaphrodite mobility and fecundity [6].
  • Using recombination and deficiency mapping we established the following gene order: let-336, unc-34, let-326, unc-60, emb-29, let-426 [6].
  • By screening simultaneously for recessive lethals closely linked to either dpy-11 or unc-60, we recovered ethyl methanesulfonate-induced mutations in 10 essential genes near dpy-11 but in only two genes near unc-60 [6].

Other interactions of unc-60


  1. The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans. Anyanful, A., Ono, K., Johnsen, R.C., Ly, H., Jensen, V., Baillie, D.L., Ono, S. J. Cell Biol. (2004) [Pubmed]
  2. UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle. Ono, S., Baillie, D.L., Benian, G.M. J. Cell Biol. (1999) [Pubmed]
  3. Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics. Ono, S., Benian, G.M. J. Biol. Chem. (1998) [Pubmed]
  4. Mutagenesis in Caenorhabditis elegans. II. A spectrum of mutational events induced with 1500 r of gamma-radiation. Rosenbluth, R.E., Cuddeford, C., Baillie, D.L. Genetics (1985) [Pubmed]
  5. Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans. Ono, K., Parast, M., Alberico, C., Benian, G.M., Ono, S. J. Cell. Sci. (2003) [Pubmed]
  6. Genetic organization of the unc-60 region in Caenorhabditis elegans. McKim, K.S., Heschl, M.F., Rosenbluth, R.E., Baillie, D.L. Genetics (1988) [Pubmed]
  7. The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins. McKim, K.S., Matheson, C., Marra, M.A., Wakarchuk, M.F., Baillie, D.L. Mol. Gen. Genet. (1994) [Pubmed]
  8. The major gut esterase locus in the nematode Caenorhabditis elegans. McGhee, J.D., Cottrell, D.A. Mol. Gen. Genet. (1986) [Pubmed]
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