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Gene Review

unc-32  -  Protein UNC-32

Caenorhabditis elegans

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High impact information on unc-32

  • Furthermore, the vha-7 and unc-32 genes were also expressed in the uteri of hermaphrodites [1].
  • We show here that unc-32 corresponds to one of the four genes encoding a V-ATPase a subunit in the nematode, and we present their expression patterns and a molecular analysis of the gene family. unc-32 gives rise via alternative splicing to at least six transcripts [2].
  • In the uncoordinated alleles, the transcript unc-32 B is affected, suggesting that it encodes an isoform that is targeted to synaptic vesicles of cholinergic neurons, where it would control neurotransmitter uptake or release [2].


  1. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka, T., Toyomura, T., Honjo, K., Wada, Y., Futai, M. J. Biol. Chem. (2001) [Pubmed]
  2. The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit. Pujol, N., Bonnerot, C., Ewbank, J.J., Kohara, Y., Thierry-Mieg, D. J. Biol. Chem. (2001) [Pubmed]
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