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Gene Review

tpk-1  -  Protein TPK-1

Caenorhabditis elegans

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High impact information on tpk-1

  • The mutation slows physiological rhythms and the phenotype it produces can be rescued by TPP but not thiamine supplementation. tpk-1 functions cell nonautonomously, as the expression of wild-type tpk-1 in one tissue can rescue the function of other tissues that express only mutant tpk-1 [1].
  • We have identified a partial loss-of-function mutation in the Caenorhabditis elegans gene (tpk-1) that encodes thiamine pyrophosphokinase, which forms TPP from thiamine at the expense of ATP inside cells [1].


  1. Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. de Jong, L., Meng, Y., Dent, J., Hekimi, S. Genetics (2004) [Pubmed]
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