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Gene Review

Tpk1  -  thiamine pyrophosphokinase

Mus musculus

Synonyms: Thiamin pyrophosphokinase 1, Thiamine pyrophosphokinase 1, mTPK1
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Disease relevance of Tpk1


High impact information on Tpk1


Biological context of Tpk1


Associations of Tpk1 with chemical compounds

  • TPK subunits associate as a dimer, and thiamin is bound in the dimer interface [5].

Analytical, diagnostic and therapeutic context of Tpk1


  1. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. Nosaka, K., Onozuka, M., Nishino, H., Nishimura, H., Kawasaki, Y., Ueyama, H. J. Biol. Chem. (1999) [Pubmed]
  2. Thiamine homeostasis in neuroblastoma cells. Bettendorff, L. Neurochem. Int. (1995) [Pubmed]
  3. Difference in thiamine metabolism between extensor digitorum longus and soleus muscles. Matsuda, T., Tonomura, H., Baba, A., Iwata, H. Comp. Biochem. Physiol., B (1989) [Pubmed]
  4. Molecular cloning of human thiamin pyrophosphokinase. Zhao, R., Gao, F., Goldman, I.D. Biochim. Biophys. Acta (2001) [Pubmed]
  5. Crystal structure of thiamin pyrophosphokinase. Timm, D.E., Liu, J., Baker, L.J., Harris, R.A. J. Mol. Biol. (2001) [Pubmed]
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