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Gene Review

TPK1  -  thiamin pyrophosphokinase 1

Homo sapiens

Synonyms: HTPK1, PP20, Placental protein 20, THMD5, Thiamin pyrophosphokinase 1, ...
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Disease relevance of TPK1


High impact information on TPK1


Biological context of TPK1


Anatomical context of TPK1


Associations of TPK1 with chemical compounds

  • The availability of the human TPK1 gene will provide another useful tool for studying the role of this enzyme in human thiamin metabolism and deficiency state [8].
  • Pyrithiamine as a substrate for thiamine pyrophosphokinase [5].
  • The kinetic properties of human thiamin pyrophosphokinase (hTPK1) were investigated using purified histidine-tagged recombinant protein [11].
  • These findings are consistent with the views that TMP is not directly converted to TPP but after being dephosphorylated by the action of a monoesterase, thiamine is pyrophosphorylated with ATP by thiamine pyrophosphokinase (EC to form TPP and thus give a clear evidence regarding the mechanism of TPP formation in plant tissues [12].

Other interactions of TPK1

  • Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21) [9].

Analytical, diagnostic and therapeutic context of TPK1


  1. Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Bellyei, S., Szigeti, A., Boronkai, A., Szabo, Z., Bene, J., Janaky, T., Barna, L., Sipos, K., Minik, O., Kravjak, A., Ohmacht, R., Melegh, B., Zavodszky, P., Than, G.N., Sumegi, B., Bohn, H., Than, N.G. Placenta (2005) [Pubmed]
  2. Isolation and characterization of a human thiamine pyrophosphokinase cDNA. Nosaka, K., Onozuka, M., Kakazu, N., Hibi, S., Nishimura, H., Nishino, H., Abe, T. Biochim. Biophys. Acta (2001) [Pubmed]
  3. Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness. Akinci, A., Teziç, T., Ertürk, G., Tarim, O., Dalva, K. Acta paediatrica Japonica; Overseas edition. (1993) [Pubmed]
  4. A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Pritchard, L., Sloane-Stanley, J.A., Sharpe, J.A., Aspinwall, R., Lu, W., Buckle, V., Strmecki, L., Walker, D., Ward, C.J., Alpers, C.E., Zhou, J., Wood, W.G., Harris, P.C. Hum. Mol. Genet. (2000) [Pubmed]
  5. Pyrithiamine as a substrate for thiamine pyrophosphokinase. Liu, J.Y., Timm, D.E., Hurley, T.D. J. Biol. Chem. (2006) [Pubmed]
  6. De novo t(7;10)(q33;q23) translocation and closely juxtaposed microdeletion in a patient with macrocephaly and developmental delay. Yue, Y., Grossmann, B., Holder, S.E., Haaf, T. Hum. Genet. (2005) [Pubmed]
  7. Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene. Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K. J. Nutr. Sci. Vitaminol. (2005) [Pubmed]
  8. Molecular cloning of human thiamin pyrophosphokinase. Zhao, R., Gao, F., Goldman, I.D. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21). Bohn, H., Winckler, W. Arch. Gynecol. (1985) [Pubmed]
  10. Thiamine-responsive anemia in DIDMOAD syndrome. Borgna-Pignatti, C., Marradi, P., Pinelli, L., Monetti, N., Patrini, C. J. Pediatr. (1989) [Pubmed]
  11. Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase. Onozuka, M., Nosaka, K. J. Nutr. Sci. Vitaminol. (2003) [Pubmed]
  12. Purification and properties of thiamine pyrophosphokinase from parsely leaf. Mitsuda, H., Takii, Y., Iwami, K., Yasumoto, K. J. Nutr. Sci. Vitaminol. (1975) [Pubmed]
  13. The immunocytochemical localization of new soluble placental tissue proteins (PP14, 16, 17, 19, 20 and PP21) in human and cynomolgus monkey placentae. Inaba, N., Sato, N., Fukazawa, I., Ota, Y., Shirotake, S., Takamizawa, H., Nozawa, S., Bohn, H. Arch. Gynecol. (1987) [Pubmed]
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