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Gene Review:

unc-49 - Protein UNC-49

Caenorhabditis elegans

Bamber, B.A. et al., McIntire, S.L. et al., Reiner, D.J. et al.

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High impact information on unc-49

Finally, the gene unc-49 is apparently necessary postsynaptically for the inhibitory effect of GABA on the body muscles and might encode a protein needed for the function of a GABAA-like receptor [1].
We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. unc-49 contains a single copy of a GABA receptor N terminus, followed by three tandem copies of a GABA receptor C terminus [2].
We also find that two other genes, unc-46 and unc-49, previously implicated in the inhibitory action of GABA on body-wall muscle, are also required for normal adult male sphincter relaxation [3].

Associations of unc-49 with chemical compounds

The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor [2].

References

Genes required for GABA function in Caenorhabditis elegans. McIntire, S.L., Jorgensen, E., Horvitz, H.R. Nature (1993) [Pubmed]
The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. Bamber, B.A., Beg, A.A., Twyman, R.E., Jorgensen, E.M. J. Neurosci. (1999) [Pubmed]
Reversal of a muscle response to GABA during C. elegans male development. Reiner, D.J., Thomas, J.H. J. Neurosci. (1995) [Pubmed]

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