The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Overlapping

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Genes, Overlapping


High impact information on Genes, Overlapping


Chemical compound and disease context of Genes, Overlapping


Biological context of Genes, Overlapping


Anatomical context of Genes, Overlapping


Associations of Genes, Overlapping with chemical compounds


Gene context of Genes, Overlapping

  • Data obtained from genomic and cDNA sequencing and from a combination of S1 mapping and primer extension experiments indicated a very unusual organization of this locus, which appeared to be composed of two partially overlapping genes, designated janA and janB [24].
  • A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain [25].
  • We have now identified a third pair of duplicated overlapping genes in this locus, termed YA and YB, whose transcriptional orientation is the same as 21A and 21B and opposite to XA and XB [26].
  • We now present the results demonstrating that in a pair of T4 overlapping genes, 30.3 and 30.3', the smaller gene, 30.3', is entirely enclosed within the other by one position downstream [27].
  • Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene [28].


  1. Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome. Lamb, R.A., Choppin, P.W., Chanock, R.M., Lai, C.J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. Construction and properties of a ribosome-binding site mutation in gene E of phi X174 bacteriophage. Gillam, S., Astell, C.R., Jahnke, P., Hutchison, C.A., Smith, M. J. Virol. (1984) [Pubmed]
  3. Two deletions within genes for simian virus 40 structural proteins VP2 and VP3 lead to formation of abnormal transcriptional complexes. Llopis, R., Stark, G.R. J. Virol. (1981) [Pubmed]
  4. Controlled expression and structural organization of a Lactococcus lactis bacteriophage lysin encoded by two overlapping genes. Shearman, C.A., Jury, K.L., Gasson, M.J. Appl. Environ. Microbiol. (1994) [Pubmed]
  5. Failure of commercial ligase chain reaction to detect Mycobacterium tuberculosis DNA in sputum samples from a patient with smear-positive pulmonary tuberculosis due to a deletion of the target region. Gilpin, C.M., Dawson, D.J., O'Kane, G., Armstrong, J.G., Coulter, C. J. Clin. Microbiol. (2002) [Pubmed]
  6. Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis. Borsani, O., Zhu, J., Verslues, P.E., Sunkar, R., Zhu, J.K. Cell (2005) [Pubmed]
  7. Role of the INK4a locus in tumor suppression and cell mortality. Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D., DePinho, R.A. Cell (1996) [Pubmed]
  8. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Umesono, K., Giguere, V., Glass, C.K., Rosenfeld, M.G., Evans, R.M. Nature (1988) [Pubmed]
  9. p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Carnero, A., Hudson, J.D., Price, C.M., Beach, D.H. Nat. Cell Biol. (2000) [Pubmed]
  10. Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. Bristow, J., Tee, M.K., Gitelman, S.E., Mellon, S.H., Miller, W.L. J. Cell Biol. (1993) [Pubmed]
  11. Chromosomal location of the Bacillus subtilis aspartokinase II gene and nucleotide sequence of the adjacent genes homologous to uvrC and trx of Escherichia coli. Chen, N.Y., Zhang, J.J., Paulus, H. J. Gen. Microbiol. (1989) [Pubmed]
  12. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Kudoh, K., Ramanna, M., Ravatn, R., Elkahloun, A.G., Bittner, M.L., Meltzer, P.S., Trent, J.M., Dalton, W.S., Chin, K.V. Cancer Res. (2000) [Pubmed]
  13. The trfB region of broad host range plasmid RK2: the nucleotide sequence reveals incC and key regulatory gene trfB/korA/korD as overlapping genes. Thomas, C.M., Smith, C.A. Nucleic Acids Res. (1986) [Pubmed]
  14. Identification of replication and stability functions in the complete nucleotide sequence of plasmid pUH24 from the cyanobacterium Synechococcus sp. PCC 7942. Van der Plas, J., Oosterhoff-Teertstra, R., Borrias, M., Weisbeek, P. Mol. Microbiol. (1992) [Pubmed]
  15. Campylobacter fetus surface layer proteins are transported by a type I secretion system. Thompson, S.A., Shedd, O.L., Ray, K.C., Beins, M.H., Jorgensen, J.P., Blaser, M.J. J. Bacteriol. (1998) [Pubmed]
  16. Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Pettersson, K., Svensson, K., Mattsson, R., Carlsson, B., Ohlsson, R., Berkenstam, A. Mech. Dev. (1996) [Pubmed]
  17. Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. Ho, S.M., Lau, K.M., Mok, S.C., Syed, V. Oncogene (2003) [Pubmed]
  18. Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species. Cheon, Y., Nara, T.Y., Band, M.R., Beever, J.E., Wallig, M.A., Nakamura, M.T. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  19. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Peart, M.J., Smyth, G.K., van Laar, R.K., Bowtell, D.D., Richon, V.M., Marks, P.A., Holloway, A.J., Johnstone, R.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  20. Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis. Banker, D.E., Eisenman, R.N. Mol. Cell. Biol. (1993) [Pubmed]
  21. The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. Bamber, B.A., Beg, A.A., Twyman, R.E., Jorgensen, E.M. J. Neurosci. (1999) [Pubmed]
  22. Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon. Meile, L., Stettler, R., Banholzer, R., Kotik, M., Leisinger, T. J. Bacteriol. (1991) [Pubmed]
  23. Distinct gene expression profiles in adult rat brains after acute MK-801 and cocaine treatments. Storvik, M., Tiikkainen, P., van Iersel, M., Wong, G. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006) [Pubmed]
  24. Transcriptional and posttranscriptional regulation contributes to the sex-regulated expression of two sequence-related genes at the janus locus of Drosophila melanogaster. Yanicostas, C., Vincent, A., Lepesant, J.A. Mol. Cell. Biol. (1989) [Pubmed]
  25. A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain. Klochkov, D., Rincón-Arano, H., Ioudinkova, E.S., Valadez-Graham, V., Gavrilov, A., Recillas-Targa, F., Razin, S.V. Mol. Cell. Biol. (2006) [Pubmed]
  26. Abundant adrenal-specific transcription of the human P450c21A "pseudogene". Bristow, J., Gitelman, S.E., Tee, M.K., Staels, B., Miller, W.L. J. Biol. Chem. (1993) [Pubmed]
  27. A rare type of overlapping genes in bacteriophage T4: gene 30.3' is completely embedded within gene 30.3 by one position downstream. Zajanckauskaite, A., Malys, N., Nivinskas, R. Gene (1997) [Pubmed]
  28. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Nicolaides, N.C., Kinzler, K.W., Vogelstein, B. Genomics (1995) [Pubmed]
WikiGenes - Universities