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Gene Review

osm-9  -  Protein OSM-9

Caenorhabditis elegans

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High impact information on osm-9

  • Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia [1].
  • In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences [2].


  1. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. de Bono, M., Tobin, D.M., Davis, M.W., Avery, L., Bargmann, C.I. Nature (2002) [Pubmed]
  2. TRPV channels' role in osmotransduction and mechanotransduction. Liedtke, W. Handbook of experimental pharmacology (2007) [Pubmed]
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