Gene Review:
nhr-8 - Protein NHR-8
Caenorhabditis elegans
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Disease relevance of nhr-8
- In contrast to pgp-3 mutants, nhr-8 mutants are not more sensitive than wild-type to pyocyanin-dependent killing by the pathogenic bacterium Pseudomonas aeruginosa [1].
High impact information on nhr-8
- Specifically, we show that a Caenorhabditis elegans member of this NR class, nhr-8, is required for wild-type levels of resistance to the toxins colchicine and chloroquine [1].
References
- A C. elegans orphan nuclear receptor contributes to xenobiotic resistance. Lindblom, T.H., Pierce, G.J., Sluder, A.E. Curr. Biol. (2001) [Pubmed]
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