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Gene Review

nhr-8  -  Protein NHR-8

Caenorhabditis elegans

 
 
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Disease relevance of nhr-8

  • In contrast to pgp-3 mutants, nhr-8 mutants are not more sensitive than wild-type to pyocyanin-dependent killing by the pathogenic bacterium Pseudomonas aeruginosa [1].
 

High impact information on nhr-8

  • Specifically, we show that a Caenorhabditis elegans member of this NR class, nhr-8, is required for wild-type levels of resistance to the toxins colchicine and chloroquine [1].

References

  1. A C. elegans orphan nuclear receptor contributes to xenobiotic resistance. Lindblom, T.H., Pierce, G.J., Sluder, A.E. Curr. Biol. (2001) [Pubmed]
 
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