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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gcy-8  -  Protein GCY-8

Caenorhabditis elegans

 
 
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High impact information on gcy-8

  • The gustatory neurons ASE left (ASEL) and ASE right (ASER) are two bilaterally symmetric neurons that sense distinct chemosensory cues and express a distinct set of four known chemoreceptors of the guanylyl cyclase (gcy) gene family [1].
  • We report the existence of a total of 27 gcy genes encoding receptor-type guanylyl cyclases and of 7 gcy genes encoding soluble guanylyl cyclases in the complete genome sequence of C. elegans [1].
  • To examine the extent of lateralization of gcy gene expression patterns in the ASE neurons, we have undertaken a genomewide analysis of all gcy genes [1].
  • Genetic and behavioral analyses showed that three members of a subfamily of gcy genes (gcy-8, gcy-18, and gcy-23) encoding guanylyl cyclases were essential for thermotaxis in C. elegans [2].

References

  1. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz, C.O., Etchberger, J.F., Posy, S.L., Frøkjaer-Jensen, C., Lockery, S., Honig, B., Hobert, O. Genetics (2006) [Pubmed]
  2. Identification of Guanylyl Cyclases That Function in Thermosensory Neurons of Caenorhabditis elegans. Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K., Mori, I. Genetics (2006) [Pubmed]
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