Gene Review:
gon-4 - Protein GON-4
Caenorhabditis elegans
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High impact information on gon-4
- gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans [1].
- In gon-4 adults, normal somatic gonadal structures are never observed, and germ-line and vulval tissues, which depend on somatic gonadal cues for their development, are also aberrant [1].
Biological context of gon-4
- In contrast, in gon-4 mutants, the Z1/Z4 cell lineages are variably aborted in both hermaphrodites and males: Z1 and Z4 divide much later than normal and subsequent divisions are either absent or severely delayed [1].
References
- gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans. Friedman, L., Santa Anna-Arriola, S., Hodgkin, J., Kimble, J. Dev. Biol. (2000) [Pubmed]
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