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Gene Review:

dnc-1 - Protein DNC-1

Caenorhabditis elegans

Dawe, A.L. et al., Severson, A.F. et al., Aumais, J.P. et al., Skop, A.R. et al., Gönczy, P. et al., et al.

Gönczy, Pichler, Kirkham, Hyman,

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High impact information on dynactin

These forces, which appear to be mediated by dynein and dynactin, produce changes in the shape and orientation of mitotic spindles [1].
Unlike MFs, dynein, and dynactin, myosin II is not required for the production of these forces [1].
These phenotypes were also observed when the dynactin components p50/dynamitin or p150(Glued) were depleted with RNAi [2].
Many cargoes link to dynein via interactions between dynactin and vesicle-associated spectrin [3].

Biological context of dynactin

Digital time-lapse video microscopy was used to determine that RNAi-treated embryos exhibited nuclear positioning defects in early embryonic cell division similar to those reported for dynein/dynactin depletion [4].

Anatomical context of dynactin

RESULTS: Here, we report that dynactin, the dynein-activator complex, is localized at cortical microtubule attachment sites and is necessary for mitotic spindle alignment in early Caenorhabditis elegans embryos [5].

Physical interactions of dynactin

NudC forms a biochemical complex with components of the dynein/dynactin complex and is suggested to play a role in translocation of nuclei in proliferating neuronal progenitors as well as in migrating neurons in culture [6].

References

Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans. Severson, A.F., Bowerman, B. J. Cell Biol. (2003) [Pubmed]
Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. Gönczy, P., Pichler, S., Kirkham, M., Hyman, A.A. J. Cell Biol. (1999) [Pubmed]
Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo. Koushika, S.P., Schaefer, A.M., Vincent, R., Willis, J.H., Bowerman, B., Nonet, M.L. J. Neurosci. (2004) [Pubmed]
Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe, A.L., Caldwell, K.A., Harris, P.M., Morris, N.R., Caldwell, G.A. Dev. Genes Evol. (2001) [Pubmed]
The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Skop, A.R., White, J.G. Curr. Biol. (1998) [Pubmed]
Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S.H., Yu-Lee, L.Y. J. Cell. Sci. (2003) [Pubmed]

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dctn1a	Danio rerio
MGG_03960	Magnaporthe oryzae 70-15
NCU03483	Neurospora crassa OR74A

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