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Gene Review

dnc-1  -  Protein DNC-1

Caenorhabditis elegans

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High impact information on dynactin

  • These forces, which appear to be mediated by dynein and dynactin, produce changes in the shape and orientation of mitotic spindles [1].
  • Unlike MFs, dynein, and dynactin, myosin II is not required for the production of these forces [1].
  • These phenotypes were also observed when the dynactin components p50/dynamitin or p150(Glued) were depleted with RNAi [2].
  • Many cargoes link to dynein via interactions between dynactin and vesicle-associated spectrin [3].

Biological context of dynactin


Anatomical context of dynactin

  • RESULTS: Here, we report that dynactin, the dynein-activator complex, is localized at cortical microtubule attachment sites and is necessary for mitotic spindle alignment in early Caenorhabditis elegans embryos [5].

Physical interactions of dynactin

  • NudC forms a biochemical complex with components of the dynein/dynactin complex and is suggested to play a role in translocation of nuclei in proliferating neuronal progenitors as well as in migrating neurons in culture [6].


  1. Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans. Severson, A.F., Bowerman, B. J. Cell Biol. (2003) [Pubmed]
  2. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. Gönczy, P., Pichler, S., Kirkham, M., Hyman, A.A. J. Cell Biol. (1999) [Pubmed]
  3. Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo. Koushika, S.P., Schaefer, A.M., Vincent, R., Willis, J.H., Bowerman, B., Nonet, M.L. J. Neurosci. (2004) [Pubmed]
  4. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe, A.L., Caldwell, K.A., Harris, P.M., Morris, N.R., Caldwell, G.A. Dev. Genes Evol. (2001) [Pubmed]
  5. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Skop, A.R., White, J.G. Curr. Biol. (1998) [Pubmed]
  6. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S.H., Yu-Lee, L.Y. J. Cell. Sci. (2003) [Pubmed]
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