Gene Review:
fos-1 - Protein FOS-1
Caenorhabditis elegans
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High impact information on fos-1
- We have identified the fos transcription factor ortholog fos-1 as a critical regulator of basement-membrane removal [1].
- In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval cells, but these processes fail to remove the basement membranes separating the gonad from the vulval epithelium. fos-1 is expressed in the anchor cell and controls invasion cell autonomously [1].
References
- FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Sherwood, D.R., Butler, J.A., Kramer, J.M., Sternberg, P.W. Cell (2005) [Pubmed]
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