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Gene Review

egl-10  -  Protein EGL-10

Caenorhabditis elegans

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High impact information on egl-10

  • Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways [1].
  • Strains overexpressing egl-10, which codes for an RGS protein negatively regulating goa-1, are also isoflurane resistant [2].


  1. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle, M.R., Horvitz, H.R. Cell (1996) [Pubmed]
  2. Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. van Swinderen, B., Metz, L.B., Shebester, L.D., Mendel, J.E., Sternberg, P.W., Crowder, C.M. Genetics (2001) [Pubmed]
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