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Chemical Compound Review

ZINC03812960     (2S)-2-chloro-2- (difluoromethoxy)-1,1,1...

Synonyms: AC1NA03C, 3f78, ICF
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Disease relevance of isoflurane


Psychiatry related information on isoflurane


High impact information on isoflurane


Chemical compound and disease context of isoflurane


Biological context of isoflurane

  • The kSM increased from 3.7 +/- 0.5 to 4.8 +/- 0.8 (p less than 0.01) with infusion of dobutamine (after reversal of beta-blockade) and decreased to 3.1 +/- 0.3 (p less than 0.05) with inhalation of isoflurane, a negative inotrope, during beta-blockade (p less than 0.05) [21].
  • CONCLUSIONS: Isoflurane attenuates cAMP-mediated vasodilation [22].
  • CONCLUSIONS: These data support a cardioprotective effect of isoflurane and, more generally, demonstrate the feasibility of pharmacologically preconditioning the human heart during cardiac surgery [15].
  • Translation initiation was inhibited by isoflurane even when eIF2alpha phosphorylation decreased and this inhibition was GCN-independent [23].
  • At columnar resolution, the specificity of intrinsic cerebral blood volume (CBV) response to orientation-selective columns in isoflurane-anesthetized cats was determined for CBV-weighted fMRI signals after injection of iron oxide at a dose of 10 mg Fe/kg [24].

Anatomical context of isoflurane


Associations of isoflurane with other chemical compounds


Gene context of isoflurane

  • The ZZZ1 and MDP1/RSP5 gene products appear to play important roles in determining effective anesthetic dose in yeast since increased levels of either gene increases isoflurane sensitivity whereas decreased activity decreases sensitivity [34].
  • The zzz3-1 mutation renders yeast isoflurane resistant and is an allele of GCN3 [23].
  • Loss-of-function mutants of the gene goa-1, which codes for the alpha-subunit of Go, have EC(50)s for the VA isoflurane of 1.7- to 2.4-fold that of wild type [35].
  • Strains overexpressing egl-10, which codes for an RGS protein negatively regulating goa-1, are also isoflurane resistant [35].
  • It is suggested that in wild-type mice, eNOS and nNOS contribute to isoflurane-induced increase in rCBF [36].

Analytical, diagnostic and therapeutic context of isoflurane

  • To study the physiological significance of changes in coronary perfusion on global and regional myocardial function in situ, the left anterior descending coronary artery of isoflurane-anesthetized swine was cannulated, and perfusion was varied [37].
  • In 10 of them, preconditioning was elicited after the onset of cardiopulmonary bypass via a 5-minute exposure to isoflurane (2.5 minimum alveolar concentration), followed by a 10-minute washout before aortic cross-clamping and cardioplegic arrest [15].
  • BACKGROUND: Experimentally, isoflurane, a commonly used volatile anesthetic agent, mimics the cardioprotective effects of ischemic preconditioning via a mechanism that could involve the activation of protein kinase C. The present study was designed to assess the clinical relevance of this observation in patients undergoing elective CABG [15].
  • When a precision vaporizer is available, isoflurane is usually the agent of choice [38].
  • To investigate this, gradient-echo BOLD fMRI in response to visual stimulus was obtained in isoflurane-anesthetized cats at 9.4 T [39].


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