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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sel-1  -  Protein SEL-1

Caenorhabditis elegans

 
 
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High impact information on sel-1

  • Previous work indicated that sel-1 functions as a negative regulator of lin-12 activity, and predicted that SEL-1 is a secreted or membrane associated protein [1].
  • We have cloned the human full-length cDNA SEL1L, which is highly similar to the C. elegans sel-1 gene, an important negative regulator of the "notch" pathway which acts as a key regulator of the cellular proliferation and specification processes in both vertebrates and invertebrates [2].
 

Other interactions of sel-1

  • The sel-1 gene was identified as an extragenic suppressor of a lin-12 hypomorphic mutant [3].

References

  1. Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Grant, B., Greenwald, I. Development (1997) [Pubmed]
  2. SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers. Biunno, I., Bernard, L., Dear, P., Cattaneo, M., Volorio, S., Zannini, L., Bankier, A., Zollo, M. Hum. Genet. (2000) [Pubmed]
  3. The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Grant, B., Greenwald, I. Genetics (1996) [Pubmed]
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