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SEL1L  -  sel-1 suppressor of lin-12-like (C. elegans)

Homo sapiens

Synonyms: IBD2, PRO1063, Protein sel-1 homolog 1, SEL1-LIKE, SEL1L1, ...
 
 
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Disease relevance of SEL1L

  • Overexpression of SEL1L in stably transfected pancreatic cancer cells caused both a decrease in clonogenicity and anchorage-independent growth as well as a significant increase in the levels of activin A and SMAD4 [1].
  • Recent data suggest that SEL1L may play an important role in pancreatic carcinoma, similar to breast cancer, where the expression of SEL1L has been associated with a reduction in both proliferative activity in vitro and clinical tumor aggressiveness [1].
  • RESULTS: The promoters of SEL1L, MUC1 and KRT19 displayed the highest activity levels in reporter gene assays while other genes reported as upregulated in gastric cancer were moderately expressed [2].
  • Analysis of a series of human primary breast carcinomas, using a monoclonal antibody raised against a SEL1L recombinant protein, revealed down-modulation or absence of SEL1L expression in about two-thirds of the tumors as compared with normal breast epithelial cells [3].
  • Our analysis revealed that 17% of adenocarcinomas of the pancreas did not express SEL1L to a detectable level; however, no gross genomic alterations were apparent in the few hundred kilobases of the relevant region [4].
 

Psychiatry related information on SEL1L

 

High impact information on SEL1L

 

Biological context of SEL1L

  • The SEL1L gene maps to 14q24.3-31 and here we report its fine localization by HAPPY mapping, which determines its molecular distance to microsatellite markers isolated in the region [10].
  • Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture [11].
  • Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population [12].
  • Gene expression modulations correlate with the decrease in invasive ability (P < .05) and in accumulation of SEL1L-expressing cells in G1 [13].
  • Taken together, our data indicate that SEL1L alters the expression of mediators involved in the remodeling of the extracellular matrix by creating a microenvironment that is unfavorable to invasive growth and by affecting cell cycle progression through promotion of G1 accumulation [13].
 

Anatomical context of SEL1L

  • The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7 [14].
  • We hypothesize that SEL1L could influence those cellular changes that mediate the transition from a normal mucosa to a neoplastic lesion and may help in the identification of those patients at higher risk of developing this cancer [15].
  • SEL1L and squamous cell carcinoma of the esophagus [15].
  • SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases [16].
  • A hybridoma secreting an antibody specifically reacting on the SEL1L recombinant fragment was selected [17].
 

Associations of SEL1L with chemical compounds

  • When driving cytosine deaminase in MKN45 cells, the SEL1L promoter induced a 66% cytotoxic effect and the TP1 promoter reached 82% [2].
 

Regulatory relationships of SEL1L

  • The present investigation therefore suggests that SEL1L may not exert a negative regulatory influence on Notch signalling [11].
 

Other interactions of SEL1L

  • RESULTS: From a selection of 9 promoter constructs SEL1L, KRT19 and MUC1 displayed the highest activity levels while others were moderately expressed [18].
  • SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions [13].
  • Taken together the present findings do not support the postulated negative regulatory role for SEL1L in Notch signalling [11].
  • No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility [19].
  • Identification of a novel polymorphism in the fibronectin type II domain of the SEL1L gene and possible relation to the persistent hyperinsulinemic hypoglycemia of infancy [20].
 

Analytical, diagnostic and therapeutic context of SEL1L

References

  1. SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. Cattaneo, M., Orlandini, S., Beghelli, S., Moore, P.S., Sorio, C., Bonora, A., Bassi, C., Talamini, G., Zamboni, G., Orlandi, R., Ménard, S., Bernardi, L.R., Biunno, I., Scarpa, A. Oncogene (2003) [Pubmed]
  2. Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer. Aberle, S., Schug, N., Mathlouthi, R., Seitz, G., Küpper, J.H., Schröder, K., Blin, N. European journal of gastroenterology & hepatology. (2004) [Pubmed]
  3. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. Orlandi, R., Cattaneo, M., Troglio, F., Casalini, P., Ronchini, C., Ménard, S., Biunno, I. Cancer Res. (2002) [Pubmed]
  4. Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. Biunno, I., Appierto, V., Cattaneo, M., Leone, B.E., Balzano, G., Socci, C., Saccone, S., Letizia, A., Della Valle, G., Sgaramella, V. Genomics (1997) [Pubmed]
  5. A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease. Saltini, G., Dominici, R., Lovati, C., Cattaneo, M., Michelini, S., Malferrari, G., Caprera, A., Milanesi, L., Finazzi, D., Bertora, P., Scarpini, E., Galimberti, D., Venturelli, E., Musicco, M., Adorni, F., Mariani, C., Biunno, I. Neurosci. Lett. (2006) [Pubmed]
  6. The genetics of inflammatory bowel disease. Bonen, D.K., Cho, J.H. Gastroenterology (2003) [Pubmed]
  7. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. Mueller, B., Lilley, B.N., Ploegh, H.L. J. Cell Biol. (2006) [Pubmed]
  8. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Cavanaugh, J. Am. J. Hum. Genet. (2001) [Pubmed]
  9. Expression of the notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Rooman, I., De Medts, N., Baeyens, L., Lardon, J., De Breuck, S., Heimberg, H., Bouwens, L. Am. J. Pathol. (2006) [Pubmed]
  10. SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers. Biunno, I., Bernard, L., Dear, P., Cattaneo, M., Volorio, S., Zannini, L., Bankier, A., Zollo, M. Hum. Genet. (2000) [Pubmed]
  11. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. Chiaramonte, R., Calzavara, E., Basile, A., Comi, P., Sherbet, G.V. Anticancer Res. (2002) [Pubmed]
  12. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. Chiaramonte, R., Sabbadini, M., Balordi, F., Comi, P., Sherbet, G.V. Mol. Cell. Biochem. (2002) [Pubmed]
  13. SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions. Cattaneo, M., Fontanella, E., Canton, C., Delia, D., Biunno, I. Neoplasia (2005) [Pubmed]
  14. Identification of a region within SEL1L protein required for tumour growth inhibition. Cattaneo, M., Canton, C., Albertini, A., Biunno, I. Gene (2004) [Pubmed]
  15. SEL1L and squamous cell carcinoma of the esophagus. Granelli, P., Cattaneo, M., Ferrero, S., Bottiglieri, L., Bosari, S., Fichera, G., Biunno, I. Clin. Cancer Res. (2004) [Pubmed]
  16. SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases. Ban, Y., Taniyama, M., Tozaki, T., Yanagawa, T., Tomita, M., Ban, Y. Thyroid (2001) [Pubmed]
  17. Production of a monoclonal antibody directed against the recombinant SEL1L protein. Orlandi, R., Cattaneo, M., Troglio, F., Campiglio, M., Biunno, I., Ménard, S. Int. J. Biol. Markers (2002) [Pubmed]
  18. Assessing optimal promoter activity for constructs in gastrointestinal gene therapy. Mathlouthi, R., Aberle, S., Schug, N., Küpper, J.H., Schröder, K., Seitz, G., Blin, N. Anticancer Res. (2003) [Pubmed]
  19. No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility. Pociot, F., Larsen, Z.M., Zavattari, P., Deidda, E., Nerup, J., Cattaneo, M., Chiaramonte, R., Comi, P., Sabbadini, M., Zollo, M., Biunno, I., Cucca, F. Diabetes Metab. Res. Rev. (2001) [Pubmed]
  20. Identification of a novel polymorphism in the fibronectin type II domain of the SEL1L gene and possible relation to the persistent hyperinsulinemic hypoglycemia of infancy. Saltini, G., Proverbio, M.C., Malferrari, G., Biagiotti, L., Boettcher, P., Dominici, R., Monferini, E., Lorenzini, E., Cattaneo, M., Antonello, D., Moore, P.S., Zamproni, I., Viscardi, M., Chiumello, G., Biunno, I. Mutat. Res. (2004) [Pubmed]
  21. Cloning and functional analysis of SEL1L promoter region, a pancreas-specific gene. Cattaneo, M., Sorio, C., Malferrari, G., Rogozin, I.B., Bernard, L., Scarpa, A., Zollo, M., Biunno, I. DNA Cell Biol. (2001) [Pubmed]
 
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