Gene Review:
lin-12 - Protein LIN-12
Caenorhabditis elegans
- Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Wilkinson, H.A., Fitzgerald, K., Greenwald, I. Cell (1994)
- Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Struhl, G., Fitzgerald, K., Greenwald, I. Cell (1993)
- Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Seydoux, G., Schedl, T., Greenwald, I. Cell (1990)
- lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor. Greenwald, I. Cell (1985)
- The lin-12 locus specifies cell fates in Caenorhabditis elegans. Greenwald, I.S., Sternberg, P.W., Horvitz, H.R. Cell (1983)
- Cell autonomy of lin-12 function in a cell fate decision in C. elegans. Seydoux, G., Greenwald, I. Cell (1989)
- Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Tax, F.E., Yeargers, J.J., Thomas, J.H. Nature (1994)
- The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Yochem, J., Weston, K., Greenwald, I. Nature (1988)
- Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Mango, S.E., Maine, E.M., Kimble, J. Nature (1991)
- lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans. Moskowitz, I.P., Rothman, J.H. Development (1996)
- SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. de Souza, N., Vallier, L.G., Fares, H., Greenwald, I. Development (2007)
- The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections. Newman, A.P., Inoue, T., Wang, M., Sternberg, P.W. Curr. Biol. (2000)
- The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function. Eimer, S., Donhauser, R., Baumeister, R. Dev. Biol. (2002)
- SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans. Fares, H., Greenwald, I. Genetics (1999)
- Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans. Zhang, D.M., Levitan, D., Yu, G., Nishimura, M., Chen, F., Tandon, A., Kawarai, T., Arawaka, S., Supala, A., Song, Y.Q., Rogaeva, E., Liang, Y., Holmes, E., Milman, P., Sato, C., Zhang, L., St George-Hyslop, P. Neuroreport (2000)
- Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans. Sundaram, M., Greenwald, I. Genetics (1993)
- Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans. Austin, J., Kimble, J. Cell (1989)
- Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Levitan, D., Greenwald, I. Development (1998)
- Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. Tax, F.E., Thomas, J.H., Ferguson, E.L., Horvitz, H.R. Genetics (1997)
- The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. Oberg, C., Li, J., Pauley, A., Wolf, E., Gurney, M., Lendahl, U. J. Biol. Chem. (2001)
- sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. Chen, J., Li, X., Greenwald, I. Genetics (2004)
- p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans. Wen, C., Greenwald, I. J. Cell Biol. (1999)
- The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Grant, B., Greenwald, I. Genetics (1996)
- Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Greenwald, I., Seydoux, G. Nature (1990)