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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fre-1  -  Protein FRE-1

Caenorhabditis elegans

 
 
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High impact information on fre-1

  • To explore expression and regulation of Nr1, we cloned fre-1, the Caenorhabditis elegans ortholog of Nr1, and discovered that it is transcribed as a bicistronic pre-mRNA together with dcs-1, the ortholog of the recently described scavenger mRNA decapping enzyme [1].
  • A novel human cytosolic flavin reductase, Nr1, was recently described that contains FMN, FAD, and NADPH cofactors [1].
 

Other interactions of fre-1

  • We find that fre-1 and dcs-1 are coordinately expressed through worm development, are induced by heat shock, and have a nearly identical expression profile in human tissues [1].

References

  1. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. Kwasnicka, D.A., Krakowiak, A., Thacker, C., Brenner, C., Vincent, S.R. J. Biol. Chem. (2003) [Pubmed]
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