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Gene Review

Ndor1  -  NADPH dependent diflavin oxidoreductase 1

Mus musculus

Synonyms: 4930447P04Rik, NADPH-dependent FMN and FAD-containing oxidoreductase, NADPH-dependent diflavin oxidoreductase 1, NR1, Ndor
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Psychiatry related information on Ndor1

  • In contrast to haloperidol, olanzapine reduced the hyperactivity in the NR1-/- mice at a dose that produced minimal effects on locomotor activity in the wild type mice [1].

High impact information on Ndor1

  • The product formed from 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen, by the action of mouse NADH:4NQO nitroreductase NR-1 was directly identified as 4-hydroxyaminoquinoline 1-oxide (4HAQO) by high performance liquid chromatography analyses in two systems [2].
  • Overall, these findings suggest that the NR1-/- mouse may provide a model for enhanced sensitivity to dopamine agonist-induced disruption of PPI [3].
  • Genetically altered mice with reductions in the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor have been proposed as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia [3].
  • Like haloperidol, risperidone and olanzapine increased PPI in both NR1+/+ and NR1-/- mice [1].

Associations of Ndor1 with chemical compounds

  • The NR1-/- mice were less sensitive to the haloperidol-induced locomotor inhibition in comparison to the NR1+/+ mice [1].


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