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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

nnt-1  -  Protein NNT-1

Caenorhabditis elegans

 
 
 
 
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High impact information on nnt-1

  • These results provide evidence for the first time that nnt-1 is important in the defense against mitochondrial oxidative stress [1].
 

Associations of nnt-1 with chemical compounds

  • Under conditions of oxidative stress, caused by the superoxide-generating agent methyl viologen, growth of worms lacking nnt-1 activity was severely impaired [1].
  • Transhydrogenase may therefore be directly involved in the defense against oxidative stress. nnt-1 deletion mutants of C. elegans, nnt-1(sv34), were isolated and shown to grow essentially as wild type under normal laboratory conditions, but with a strongly lowered GSH/GSSG ratio [1].

References

  1. A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress. Arkblad, E.L., Tuck, S., Pestov, N.B., Dmitriev, R.I., Kostina, M.B., Stenvall, J., Tranberg, M., Rydström, J. Free Radic. Biol. Med. (2005) [Pubmed]
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