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Gene Review:

NNT - nicotinamide nucleotide transhydrogenase

Homo sapiens

Synonyms: NAD(P) transhydrogenase, mitochondrial, Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase

Forsmark-Andrée, P. et al., Arkblad, E.L. et al., Phelps, D.C. et al., Zieger, B. et al., Ramirez Gaite, M.

Radi, Dallner, Ernster, Persson, Forsmark-Andrée, Marta Ramirez Gaite,

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High impact information on NNT

Inhibition of the mitochondrial nicotinamide nucleotide transhydrogenase by dicyclohexylcarbodiimide and diethylpyrocarbonate [1].

Biological context of NNT

Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase [2] .
It is concluded that the mitochondrial nicotinamide nucleotide transhydrogenase is sensitive to oxidative stress and that the mechanism underlying this can vary according to the challenge to which the enzyme is exposed [3].

Anatomical context of NNT

Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol [3].

Associations of NNT with chemical compounds

Proton-translocating nicotinamide nucleotide transhydrogenase is located in the mitochondrial inner membrane and catalyzes the reduction of NADP(+) by NADH to NADPH and NAD(+) [4].
The present paper describes the sensitivity of the mitochondrial nicotinamide nucleotide transhydrogenase (EC 1.6.1.1) to oxidative modification, and the effects of endogenous ubiquinol on this modification [3].

References

Inhibition of the mitochondrial nicotinamide nucleotide transhydrogenase by dicyclohexylcarbodiimide and diethylpyrocarbonate. Phelps, D.C., Hatefi, Y. J. Biol. Chem. (1981) [Pubmed]
Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase. Zieger, B., Ware, J. DNA Seq. (1997) [Pubmed]
Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol. Forsmark-Andrée, P., Persson, B., Radi, R., Dallner, G., Ernster, L. Arch. Biochem. Biophys. (1996) [Pubmed]
Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C elegans. Arkblad, E.L., Egorov, M., Shakhparonov, M., Romanova, L., Polzikov, M., Rydström, J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]

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