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Gene Review

NNT  -  nicotinamide nucleotide transhydrogenase

Homo sapiens

Synonyms: NAD(P) transhydrogenase, mitochondrial, Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase
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High impact information on NNT


Biological context of NNT


Anatomical context of NNT


Associations of NNT with chemical compounds

  • Proton-translocating nicotinamide nucleotide transhydrogenase is located in the mitochondrial inner membrane and catalyzes the reduction of NADP(+) by NADH to NADPH and NAD(+) [4].
  • The present paper describes the sensitivity of the mitochondrial nicotinamide nucleotide transhydrogenase (EC to oxidative modification, and the effects of endogenous ubiquinol on this modification [3].


  1. Inhibition of the mitochondrial nicotinamide nucleotide transhydrogenase by dicyclohexylcarbodiimide and diethylpyrocarbonate. Phelps, D.C., Hatefi, Y. J. Biol. Chem. (1981) [Pubmed]
  2. Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase. Zieger, B., Ware, J. DNA Seq. (1997) [Pubmed]
  3. Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol. Forsmark-Andrée, P., Persson, B., Radi, R., Dallner, G., Ernster, L. Arch. Biochem. Biophys. (1996) [Pubmed]
  4. Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C elegans. Arkblad, E.L., Egorov, M., Shakhparonov, M., Romanova, L., Polzikov, M., Rydström, J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]
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